Acetate supplementation restores testicular function by modulating Nrf2/PPAR-[gamma] in high fat diet-induced obesity in Wistar rats

• Published in: Journal of diabetes and metabolic disorders
• Main Authors: Olaniyi, Kehinde S, Akintayo, Christopher O, Oniyide, Adesola A, Omoaghe, Adams O, Oyeleke, Mosunmola B, Fafure, Adedamola A
• Format: Journal Article
• Language: English
• Published: BioMed Central Ltd 21.10.2021
• Subjects: Acetates; Blood sugar; Body weight; Comorbidity; Diet; Fatty acids; Follicle-stimulating hormone; Glycoproteins; Leptin; Luteinizing hormone; Nitric oxide; Obesity in children; Testosterone; Nigeria; United Kingdom; China

Purpose Several studies have established impaired testicular function in obese male population, including the young males with childhood obesity, contributing to increased male infertility, which is a universal trend in the last few decades. Short chain fatty acids (SCFAs) have been recently demonst...