Specific involvement of atypical PKC?/PKM? in spinal persistent nociceptive processing following peripheral inflammation in rat

• Published in: Molecular pain Vol. 7; p. 86
• Main Authors: Marchand, Fabien, D'Mello, Richard, Yip, Ping K, Calvo, Margarita, Muller, Emilie, Pezet, Sophie, Dickenson, Anthony H, McMahon, Stephen B
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 05.11.2011; Sage Publications Ltd
• Subjects: Behavior; Experiments; Human subjects; Inflammation; Kinases; Neurons; Peptides; Physiological aspects; Protein kinases; Proteins; Rodents; France; United Kingdom

Background Central sensitization requires the activation of various intracellular signalling pathways within spinal dorsal horn neurons, leading to a lowering of activation threshold and enhanced responsiveness of these cells. Such plasticity contributes to the manifestation of chronic pain states a...