Evaluating elexacaftor/tezacaftor/ivacaftor : A clinical study protocol

• Published in: PloS one Vol. 20; no. 2; p. e0316721
• Main Authors: Swenson, Colin E, Hunt, William R, Manfredi, Candela, Beltran, Diana J, Hong, Jeong S, Davis, Brian R, Suzuki, Shingo, Barillá, Cristina, Rab, Andras, Chico, Cynthia, Dangerfield, Joy, Streby, Ashleigh, Barton, Erin, Cox, Elizabeth M, Stecenko, Arlene A, Westbrook, Adrianna, Kapolka, Rebecca, Sorscher, Eric J
• Format: Journal Article
• Language: English
• Published: Public Library of Science 14.02.2025
• Subjects: Bronchiectasis; Diagnosis; Dosage and administration; Drug therapy; Drug therapy, Combination; Ivacaftor; Patient outcomes; Testing; United States

Background Non-cystic fibrosis bronchiectasis (NCFBE) is a disease that exhibits dilatation of airways, airflow obstruction, persistent cough, excessive sputum production, and refractory respiratory infections. NCFBE exhibits clinical and pathological manifestations similar to key features of cystic...