Vascular normalization in orthotopic glioblastoma following intravenous treatment with lipid-based nanoparticulate formulations of irinotecan or vincristine

• Published in: BMC cancer Vol. 11; p. 124
• Main Authors: Verreault, Maite, Strutt, Dita, Masin, Dana, Anantha, Malathi, Yung, Andrew, Kozlowski, Piotr, Waterhouse, Dawn, Bally, Marcel B, Yapp, Donald T
• Format: Journal Article
• Language: English
• Published: BioMed Central Ltd 08.04.2011
• Subjects: Blood-vessels; Care and treatment; Dosage and administration; Doxorubicin; Glioblastoma multiforme; Patient outcomes; Tumors; Vincristine

Background Chemotherapy for glioblastoma (GBM) patients is compromised in part by poor perfusion in the tumor. The present study evaluates how treatment with liposomal formulation of irinotecan (Irinophore C[TM]), and other liposomal anticancer drugs, influence the tumor vasculature of GBM models gr...