The DR1-CSE/[H.sub.2]S system inhibits renal fibrosis by downregulating the ERK1/2 signaling pathway in diabetic mice

• Published in: International journal of molecular medicine Vol. 49; no. 1; p. 1
• Main Authors: Li, Hongzhu, Sun, Fengqi, Bai, Shuzhi, Chang, Guiquan, Wu, Ren, Wei, Yaxin, Wen, Xin, Xi, Yuxin, Hao, Jinghui, Zaid, Altaany
• Format: Journal Article
• Language: English
• Published: Spandidos Publications 01.01.2022
• Subjects: Diabetic nephropathies; Dopamine; Hydrogen sulfide; Muscle proteins; China

Glomerular mesangial cell (MC) proliferation and extracellular matrix deposition are the main pathological changes in diabetic nephropathy. Hydrogen sulfide (H2S) inhibits the proliferation of MCs. Dopamine 1 receptors (DR1) are expressed in MCs and serve important physiological roles. However, it i...