A ICistus incanus/I Extract Blocks Psychological Stress Signaling and Reduces Neurogenic Inflammation and Signs of Aging in Skin, as Shown in In-Vitro Models and a Randomized Clinical Trial

• Published in: Cosmetics (Basel) Vol. 10; no. 1
• Main Authors: Havas, Fabien, Cohen, Moshe, Krispin, Shlomo, Loing, Estelle, Attia-Vigneau, Joan
• Format: Journal Article
• Language: English
• Published: MDPI AG 01.12.2022
• Subjects: ACTH; Care and treatment; Clinical trials; Cytokines; Dilleniidae; Inflammation; Medical research; Medicine, Experimental; Physiological aspects; Skin; Stress (Psychology); France; Israel

Psychological stress exerts its effects mainly through the release of corticotropin releasing hormone (CRH), which activates inflammatory pathways in skin (inter alia), resulting in redness, extracellular matrix degradation, loss of skin elasticity and firmness, and the appearance of wrinkles—namely...