Clinical Significance of the Psoas Muscle Index in Patients with Locally Advanced Gastric Cancer Receiving Perioperative Chemotherapy/Perioperatif Kemoterapi Alan Lokal Ileri Mide Kanserli Hastalarda Psoas Kas Indeksinin Klinik Onemi

• Published in: Southern Clinics of Istanbul Eurasia (SCIE) Vol. 34; no. 3; p. 205
• Main Authors: Aydiner, Omer, Dogan, Akif, Alan, Ozkan, Yildirim, Sedat, Akdag, Goncagul, Yasar, Zeynep Yuksel, Yildirim, Mahmut Emre, Buyukozsoy, Aysegul Karadayi, Odabas, Hatice, Turan, Nedim
• Format: Journal Article
• Language: Turkish
• Published: KARE Publishing 01.09.2023
• Subjects: Cancer; Cancer patients; Care and treatment; Chemotherapy; CT imaging; Development and progression; Diagnosis; Evaluation; Health aspects; Medical research; Medicine, Experimental; Muscle strength; Prognosis; Risk factors; Sarcopenia; Stomach cancer; Turkey
• ISSN: 2587-0998
• DOI: 10.14744/scie.2023.94695

Objective: The psoas muscle index (PMI) obtained with a single muscle measurement on routine computed tomography (CT) performed for staging in locally advanced gastric cancer (LAGC) is helpful in predicting whole-body sarcopenia. The objective of this trial was to determine the relationship between PMI and overall survival (OS) and disease- free survival (DFS). Methods: This retrospective cohort was conducted with 122 patients with LAGC who underwent perioperative chemotherapy and curative surgery in our center between January 2015 and December 2021. PMI and psoas muscle density were calculated at the L3 vertebra level using routine CT performed for staging after the LAGC diagnosis, and its relationship with OS and DFS was examined. Results: Twenty-nine of 122 patients were women. FLOT was the most common chemotherapy regimen and total gastrectomy was performed most frequently. The patients were divided into two groups according to the PMI values. OS and DFS were unachievable in the high PMI group, while OS and PFS were determined as 19 and 16 months, respectively, in the low PMI group. There was a statistically significant difference between the high and low PMI groups in terms of the two survival parameters (p=0.03 and p=0.001, respectively). Conclusion: PMI measured on CT performed for staging in patients diagnosed with LAGC is an important and practical method in predicting the prognosis of the disease. Keywords: Computed tomography; gastric cancer; perioperative treatment; psoas muscle index. Amac: Lokal ileri mide kanserinde (LIMK) evreleme icin yapilan rutin bilgisayarli tomografide (BT) tek kas olcumu ile elde edilen psoas kas indeksi (PMI), tum vucut sarkopenisini ongormede yardimcidir. Bu calisma ile amacimiz PMI ile genel sagkalim (GSK) ve hastaliksiz sagkalim (HSK) arasindaki iliskiyi belirlemektir. Gerec ve Yontem: Bu retrospektif kohort, Ocak 2015 ile Aralik 2021 arasinda merkezimizde perioperatif kemoterapi ve kuratif cerrahi uygulanan LIMK'li 122 hasta ile gerceklestirildi. PMI ve Psoas kas yogunlugu (PMD), evreleme icin yapilan rutin BT kullanilarak L3 vertebra seviyesinde hesaplandi. LAGC tanisindan sonra, OS ve DFS ile iliskisi incelendi. Bulgular: 122 hastanin 29'u kadindi. FLOT en yaygin kemoterapi rejimiydi ve en sik total gastrektomi uygulandi. PMI degerlerine gore hastalar iki gruba ayrildi. Yuksek PMI grubunda OS ve DFS ulasilamazken, dusuk PMI grubunda OS ve PFS sirasiyla 19 ve PFS 16 ay olarak belirlendi. Iki sagkalim parametresi acisindan yuksek ve dusuk PMI gruplari arasinda istatistiksel olarak anlamli fark vardi (sirasiyla, p=0.03 ve p=0.001). Sonuc: LIMK tanili hastalarda evreleme amaciyla yapilan BT'de olculen PMI, hastaligin prognozunu tahmin etmede onemli ve pratik bir yontemdir. Anahtar Sozcukler: Bilgisayarli tomografi; mide kanseri; perioperatif tedavi; psoas kas indeksi.