Claudin-4-adhesion signaling drives breast cancer metabolism and progression via liver X receptor [beta]

• Published in: Breast cancer research : BCR Vol. 25; no. 1
• Main Authors: Murakami-Nishimagi, Yuko, Sugimoto, Kotaro, Kobayashi, Makoto, Tachibana, Kazunoshin, Kojima, Manabu, Okano, Maiko, Hashimoto, Yuko, Saji, Shigehira, Ohtake, Tohru, Chiba, Hideki
• Format: Journal Article
• Language: English
• Published: BioMed Central Ltd 14.04.2023
• Subjects: Analysis; Breast cancer; Development and progression; Fatty acids; Gene expression; Genes; Immunohistochemistry; Liver; Physiological aspects; Proteins; RNA sequencing

Background Cell adhesion is indispensable for appropriate tissue architecture and function in multicellular organisms. Besides maintaining tissue integrity, cell adhesion molecules, including tight-junction proteins claudins (CLDNs), exhibit the signaling abilities to control a variety of physiologi...