A study of atypical reaction of methyl -acetate with 3a-substituted bicyclic [beta]-keto-[gamma]-sultams

• Published in: Chemistry of heterocyclic compounds (New York, N.Y. 1965) Vol. 57; no. 2; p. 207
• Main Authors: Omelian, Taras V, Iegorov, Pavlo O, Poliudov, Anton O, Dobrydnev, Alexey V, Ostapchuk, Eugeniy N, Volovenko, Yulian M
• Format: Journal Article
• Language: English
• Published: Springer 01.02.2021
• Subjects: Drug discovery; Sulfonamides

A number of 2-substituted 4-7-membered cyclic amino acid esters bearing endocyclic amino group were sequentially mesylated and cyclized via the CSIC reaction strategy to give the key precursors 3a-substituted bicyclic isothiazolidin-4-one 1,1-dioxides. Further reaction with methyl (triphenylphosphor...