Comparison of the Single Cell Immune Landscape between Subjects with High IMycobacterium tuberculosis/I Bacillary Loads during Active Pulmonary Tuberculosis and Household Members with Latent Tuberculosis Infection

• Published in: Cells (Basel, Switzerland) Vol. 13; no. 4
• Main Authors: Kamolratanakul, Supitcha, Ariyanon, Wassawon, Udompornpitak, Kanyarat, Bhunyakarnjanarat, Thansita, Leelahavanichkul, Asada, Dhitavat, Jittima, Wilairatana, Polrat, Chancharoenthana, Wiwat
• Format: Journal Article
• Language: English
• Published: MDPI AG 01.02.2024
• Subjects: Blood cells; Development and progression; Diagnosis; Health aspects; Immune system; Measurement; Pulmonary tuberculosis; Thailand

It is unclear how the immune system controls the transition from latent tuberculosis (TB) infection (LTBI) to active pulmonary infection (PTB). Here, we applied mass spectrometry cytometry time-of-flight (CyTOF) analysis of peripheral blood mononuclear cells to compare the immunological landscapes i...