Secretory Leucoprotease Inhibitor Promotes Survival during Acute IPseudomonas aeruginosa/I Infection by Suppression of Inflammation Rather Than Microbial Killing

• Published in: Biomolecules (Basel, Switzerland) Vol. 12; no. 12
• Main Authors: Osbourn, Megan, Rodgers, Aoife M, Dubois, Alice V, Small, Donna M, Humphries, Fiachra, Delagic, Nezira, Moynagh, Paul N, Weldon, Sinéad, Taggart, Clifford C, Ingram, Rebecca J
• Format: Journal Article
• Language: English
• Published: MDPI AG 01.11.2022
• Subjects: Care and treatment; Protease inhibitors; Pseudomonas aeruginosa infections; Testing; United Kingdom

Secretory leucoprotease inhibitor (SLPI) has multifaceted functions, including inhibition of protease activity, antimicrobial functions, and anti-inflammatory properties. In this study, we show that SLPI plays a role in controlling pulmonary Pseudomonas aeruginosa infection. Mice lacking SLPI were h...