ICDH1/I Gene Methylation in Human Breast Cancer: Critical Appraisal of a Long and Twisted Story

• Published in: Cancers Vol. 14; no. 18
• Main Authors: Bücker, Lara, Lehmann, Ulrich
• Format: Journal Article
• Language: English
• Published: MDPI AG 01.09.2022
• Subjects: Breast cancer; Cadherins; Development and progression; Genetic aspects; Health aspects; Methylation; Germany

Genes can be inactivated by specific modifications of DNA bases, most often by adding a methyl group to the DNA base cytosine if it is followed by guanosine (CG methylation). This modification prevents gene expression and has been reported for many different genes in nearly all types of cancer. A pr...