The Bioavailability of Glycyrrhizinic Acid Was Enhanced by Probiotic ILactobacillus rhamnosus/I R0011 Supplementation in Liver Fibrosis Rats

• Published in: Nutrients Vol. 14; no. 24
• Main Authors: Li, Huifang, Wang, Jing, Fu, Yifan, Zhu, Ke, Dong, Zhiling, Shan, Jinjun, Di, Liuqing, Jiang, Shu, Yuan, Tianjie
• Format: Journal Article
• Language: English
• Published: MDPI AG 01.12.2022
• Subjects: Bioavailability; Care and treatment; Drug resistance in microorganisms; Health aspects; Liver; Liver diseases; Microbiota (Symbiotic organisms); Physiological aspects; Probiotics; Saponins; China

Glycyrrhizinic acid (GL) is clinically applied to treat liver injury, and the bioavailability of orally administered GL is closely related to the gut microbiota. Therefore, the dysbiosis of gut flora in liver injury could significantly influence GL bioavailability. Still, less is known about the imp...