Effect of [gamma]-secretase inhibitor on Th17 cell differentiation and function of mouse psoriasis-like skin inflammation

Background Th17 cells and its effective cytokine IL-17A play an important role in the pathogenesis of abnormal immune responses in psoriasis. Notch1 signaling has been implicated in Th17 cell differentiation and function. In this study, our aim was to evaluate the possible inhibitory effect of Notch...

Full description

Saved in:
Bibliographic Details
Published inJournal of translational medicine Vol. 16; no. 1
Main Authors Ma, Lei, Xue, Haibo, Qi, Ruiqun, Wang, Yanqin, Yuan, Libing
Format Journal Article
LanguageEnglish
Published BioMed Central Ltd 10.03.2018
Subjects
Care and treatment
Cell differentiation
Gene expression
Genetic aspects
Membrane proteins
Psoriasis
Online AccessGet full text

Cover

Be the first to leave a comment!
You must be logged in first