Immune inhibitory function of bovine CTLA-4 and the effects of its blockade in IFN-[gamma] production

• Published in: BMC veterinary research
• Main Authors: Watari, Kei, Konnai, Satoru, Maekawa, Naoya, Okagawa, Tomohiro, Suzuki, Yasuhiko, Murata, Shiro, Ohashi, Kazuhiko
• Format: Journal Article
• Language: English
• Published: BioMed Central Ltd 29.10.2019
• Subjects: Antibodies; Antigens; B cells; Beef cattle; Biological response modifiers; Chronic diseases; Diagnosis; Gene expression; Genetic aspects; HIV infections; Homeostasis; Immune response; Infection; Interferon; Leukemia; Lymphocytes; Monoclonal antibodies; Risk factors; T cells; Tumors

Background Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is known as an immune inhibitory receptor that is expressed on activated effector T cells and regulatory T cells. When CTLA-4 binds to CD80 or CD86, immunoinhibitory signals are transmitted to retain a homeostasis of the immune response. Recent st...