The Role of Secreted Protein Acidic and Rich in Cysteine on Trinitrobenzene Sulfonic Acid-Induced Colitis in Mice

• Published in: Digestive diseases and sciences Vol. 60; no. 9; p. 2556
• Main Authors: Tanaka, Makoto, Takagi, Tomohisa, Uchiyama, Kazuhiko, Hotta, Yuma, Mizushima, Katsura, Higashimura, Yasuki, Okayama, Tetsuya, Katada, Kazuhiro, Kamada, Kazuhiro, Handa, Osamu, Ishikawa, Takeshi, Naito, Yuji, Itoh, Yoshito
• Format: Journal Article
• Language: English
• Published: Springer 23.05.2022
• Subjects: Analysis; Colitis; Cysteine; Cystine; Inflammation; T cells; Thiols

Background: SPARC (Secreted Protein Acidic and Rich in Cysteine) is a secreted matricellular protein involved in the modulation of cell adhesion and motility. We have revealed that exercise stimulates SPARC secretion from muscle tissues and inhibits colon tumorigenesis (Gut 2013, 62: 882) as well as...