Galectin-3 is elevated in CSF and is associated with A[beta] deposits and tau aggregates in brain tissue in Alzheimer's disease

• Published in: Acta neuropathologica Vol. 144; no. 5; p. 843
• Main Authors: Boza-Serrano, Antonio, Vrillon, Agathe, Minta, Karolina, Paulus, Agnes, Camprubí-Ferrer, Lluís, Garcia, Megg, Andreasson, Ulf
• Format: Journal Article
• Language: English
• Published: Springer 01.11.2022
• Subjects: Advertising executives; Alzheimer's disease; Analysis; Brain; Development and progression; Inflammation; Protein binding

Galectin-3 (Gal-3) is a beta-galactosidase binding protein involved in microglial activation in the central nervous system (CNS). We previously demonstrated the crucial deleterious role of Gal-3 in microglial activation in Alzheimer's disease (AD). Under AD conditions, Gal-3 is primarily expres...