Macrophage polarization toward M1 phenotype through NF-κB signaling in patients with Behçet's disease

• Published in: Arthritis research & therapy Vol. 24; no. 1
• Main Authors: Wu, Xiuhua, Wang, Zhimian, Shi, Jing, Yu, Xin, Li, Chaoran, Liu, Jinjing, Zhang, Fengchun, Chen, Hua, Zheng, Wenjie
• Format: Journal Article
• Language: English
• Published: BioMed Central Ltd 04.11.2022
• Subjects: Analysis; Behcet's disease; Care and treatment; Diagnosis; Health aspects; Macrophages; Phenotype; T cells; China

Background Macrophages are key innate immune cells implicated in the pathogenesis of Behçet's disease (BD), and macrophage polarization plays a pivotal role in inflammatory response. This study aimed to investigate the role of BD serum on the phenotypes and functions of macrophage polarization....