Collusion of [alpha]-Synuclein and A[beta] aggravating co-morbidities in a novel prion-type mouse model

• Published in: Molecular neurodegeneration Vol. 16; no. 1
• Main Authors: Lloyd, Grace M, Dhillon, Jess-Karan S, Gorion, Kimberly-Marie M, Riffe, Cara, Fromholt, Susan E, Xia, Yuxing, Giasson, Benoit I, Borchelt, David R
• Format: Journal Article
• Language: English
• Published: BioMed Central Ltd 09.09.2021
• Subjects: Alzheimer's disease; Analysis; Brain; Genetic engineering; Medical research; Medicine, Experimental; Nervous system diseases; Prions; California

Background The misfolding of host-encoded proteins into pathological prion conformations is a defining characteristic of many neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and Lewy body dementia. A current area of intense study is the way in which the pat...