Infection of bat and human intestinal organoids by SARS-CoV-2

• Published in: Nature medicine Vol. 26; no. 7; pp. 1077 - 1083
• Main Authors: Zhou, Jie, Li, Cun, Liu, Xiaojuan, Chiu, Man Chun, Zhao, Xiaoyu, Wang, Dong, Wei, Yuxuan, Lee, Andrew, Zhang, Anna Jinxia, Chu, Hin, Cai, Jian-Piao, Yip, Cyril Chik-Yan, Chan, Ivy Hau-Yee, Wong, Kenneth Kak-Yuen, Tsang, Owen Tak-Yin, Chan, Kwok-Hung, Chan, Jasper Fuk-Woo, To, Kelvin Kai-Wang, Chen, Honglin, Yuen, Kwok Yung
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.07.2020; Nature Publishing Group
• Subjects: 631/326/596/2078; 631/326/596/2557; Animals; Bats; Betacoronavirus - pathogenicity; Biomedical and Life Sciences; Biomedicine; Cancer Research; Cell culture; Cell Differentiation; Cells, Cultured; Child, Preschool; Chiroptera - virology; Chlorocebus aethiops; Coronaviridae; Coronavirus Infections - pathology; Coronavirus Infections - transmission; Coronavirus Infections - virology; Coronaviruses; COVID-19; Diarrhea; Disease transmission; Enterocytes - pathology; Enterocytes - physiology; Enterocytes - virology; Epithelium; Female; Gastrointestinal symptoms; Genomes; Health aspects; Homology; Humans; Infant; Infections; Infectious Diseases; Intestinal Mucosa - pathology; Intestinal Mucosa - virology; Intestine; Intestines; Intestines - pathology; Intestines - virology; Letter; Male; Metabolic Diseases; Methods; Molecular Medicine; Neurosciences; Nucleotide sequence; Organoids; Organoids - pathology; Organoids - virology; Pandemics; Physiological aspects; Pneumonia, Viral - pathology; Pneumonia, Viral - transmission; Pneumonia, Viral - virology; Replication; Respiratory diseases; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleic acid; RNA; Robustness; SARS-CoV-2; Sequence analysis; Severe acute respiratory syndrome coronavirus 2; Vero Cells; Viral diseases; Viral Load - genetics; Viral Load - methods; Viral Tropism - physiology; Viruses; China
• ISSN: 1078-8956; 1546-170X; 1546-170X
• DOI: 10.1038/s41591-020-0912-6

A novel coronavirus—severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)—emerged in humans in Wuhan, China, in December 2019 and has since disseminated globally 1 , 2 . As of April 16, 2020, the confirmed case count of coronavirus disease 2019 (COVID-19) had surpassed 2 million. Based on ful...