Insulin Resistance, Defective Insulin-Mediated Fatty Acid Suppression, and Coronary Artery Calcification in Subjects With and Without Type 1 Diabetes: The CACTI Study

• Published in: Diabetes (New York, N.Y.) Vol. 60; no. 1; pp. 306 - 314
• Main Authors: SCHAUER, Irene E, SNELL-BERGEON, Janet K, BERGMAN, Bryan C, MAAHS, David M, KRETOWSKI, Adam, ECKEL, Robert H, REWERS, Marian
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.01.2011
• Subjects: Abdomen - anatomy & histology; Absorptiometry, Photon - methods; Adipose Tissue - anatomy & histology; Adult; Age; Atherosclerosis; Biological and medical sciences; Blood Glucose - metabolism; Body Composition; Calcification; Calcium - blood; Cardiovascular disease; Cohort Studies; Complications; Complications and side effects; Coronary heart disease; Coronary vessels; Coronary Vessels - metabolism; Development and progression; Diabetes; Diabetes Mellitus, Type 1 - complications; Diabetes Mellitus, Type 1 - metabolism; Diabetes Mellitus, Type 1 - physiopathology; Diabetes. Impaired glucose tolerance; Diabetic Angiopathies - mortality; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Environmental Monitoring; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Fatty acids; Fatty Acids - metabolism; Fatty Acids, Nonesterified - blood; Female; Glucose Clamp Technique - methods; Glucose monitoring; Glycerol - blood; Humans; Hyperglycemia; Hyperinsulinism; Insulin - pharmacology; Insulin resistance; Insulin Resistance - physiology; Liver - anatomy & histology; Male; Medical sciences; Middle Aged; Physiological aspects; Reference Values; Research design; Risk factors; Spleen - anatomy & histology; Tomography; Tomography, X-Ray Computed; Type 1 diabetes; Vein & artery diseases; Women; Young Adult; United States; Endocrinopathy; Human; Immunopathology; Pancreatic hormone; Suppression; Coronary artery; Lipids; Autoimmune disease; Metabolic diseases; Fatty acids; Insulin; Target tissue resistance; Type 1 diabetes; Calcification; Insulin resistance

To assess insulin action on peripheral glucose utilization and nonesterified fatty acid (NEFA) suppression as a predictor of coronary artery calcification (CAC) in patients with type 1 diabetes and nondiabetic controls. Insulin action was measured by a three-stage hyperinsulinemic-euglycemic clamp (...