High-Dose Resveratrol Supplementation in Obese Men: An Investigator-Initiated, Randomized, Placebo-Controlled Clinical Trial of Substrate Metabolism, Insulin Sensitivity, and Body Composition

• Published in: Diabetes (New York, N.Y.) Vol. 62; no. 4; pp. 1186 - 1195
• Main Authors: POULSEN, Morten M, VESTERGAARD, Poul F, CLASEN, Berthil F, RADKO, Yulia, CHRISTENSEN, Lars P, STØDKILDE-JØRGENSEN, Hans, MØLLER, Niels, JESSEN, Niels, PEDERSEN, Steen B, JØRGENSEN, Jens Otto L
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.04.2013
• Subjects: Adolescent; Adult; Aged; Antioxidants - administration & dosage; Antioxidants - therapeutic use; Biological and medical sciences; Biomarkers; Biopsy; Blood pressure; Body Composition - drug effects; Body fat; Care and treatment; Catheters; Complications and side effects; Diabetes; Diabetes. Impaired glucose tolerance; Dietary Supplements; Dosage and administration; Dose-Response Relationship, Drug; Double-Blind Method; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Energy Metabolism - drug effects; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Gene Expression Regulation; Genetic aspects; Glucose; Glucose metabolism; Human subjects; Humans; Insulin; Insulin Resistance - physiology; Investigations; Male; Medical sciences; Metabolic diseases; Metabolism; Middle Aged; Obesity; Obesity - drug therapy; Original Research; Oxidation; Physiological aspects; Pilot Projects; Resveratrol; Stilbenes - administration & dosage; Stilbenes - therapeutic use; Young Adult; Denmark; Endocrinopathy; Human; Obesity; Pancreatic hormone; Diabetes mellitus; Nutrition disorder; Metabolism; Insulin; Stilbene derivatives; Body composition; Polyphenol; Sensitivity; Resveratrol; Phenols; Clinical trial; Proanthocyanidin; Supplementation; High dose; Nutritional status

Obesity, diabetes, hypertension, and hyperlipidemia constitute risk factors for morbidity and premature mortality. Based on animal and in vitro studies, resveratrol reverts these risk factors via stimulation of silent mating type information regulation 2 homolog 1 (SIRT1), but data in human subjects...