Long-term wireless streaming of neural recordings for circuit discovery and adaptive stimulation in individuals with Parkinson’s disease

• Published in: Nature biotechnology Vol. 39; no. 9; pp. 1078 - 1085
• Main Authors: Gilron, Ro’ee, Little, Simon, Perrone, Randy, Wilt, Robert, de Hemptinne, Coralie, Yaroshinsky, Maria S., Racine, Caroline A., Wang, Sarah S., Ostrem, Jill L., Larson, Paul S., Wang, Doris D., Galifianakis, Nick B., Bledsoe, Ian O., San Luciano, Marta, Dawes, Heather E., Worrell, Gregory A., Kremen, Vaclav, Borton, David A., Denison, Timothy, Starr, Philip A.
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.09.2021; Nature Publishing Group
• Subjects: 631/378/1689/1718; 631/378/1697; Adaptation, Physiological; Adult; Agriculture; Analysis; Basal ganglia; Bioinformatics; Biomarkers; Biomedical and Life Sciences; Biomedical Engineering/Biotechnology; Biomedicine; Biotechnology; Brain; Brain stimulation; Care and treatment; Circuits; Computer applications; Cortex (motor); Deep Brain Stimulation; Disorders; Female; Ganglia; Humans; Implantation; Implants; Implants, Artificial; Life Sciences; Male; Methods; Middle Aged; Motor Cortex - physiopathology; Movement; Movement disorders; Neural coding; Neural prostheses; Neural recording; Neurodegenerative diseases; Neuromodulation; Neurophysiological Monitoring - methods; Parkinson Disease - physiopathology; Parkinson Disease - therapy; Parkinson's disease; Prosthesis; Sensors; Stimulation; Wearable Electronic Devices; Wireless Technology; United States

Neural recordings using invasive devices in humans can elucidate the circuits underlying brain disorders, but have so far been limited to short recordings from externalized brain leads in a hospital setting or from implanted sensing devices that provide only intermittent, brief streaming of time ser...