Treatment Of Indian Visceral Leishmaniasis With Single Or Daily Infusions Of Low Dose Liposomal Amphotericin B: Randomised Trial

• Published in: BMJ (Online) Vol. 323; no. 7310; pp. 419 - 422
• Main Authors: Sundar, Shyam, Agrawal, G., Rai, Madhukar, Makharia, M. K., Murray, Henry W.
• Format: Journal Article
• Language: English
• Published: London British Medical Association 25.08.2001; BMJ Publishing Group Ltd; BMJ Group
• Subjects: Adolescent; Adult; Amphotericin B; Amphotericin B - administration & dosage; Amphotericin B - adverse effects; Amphotericin B - therapeutic use; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antimony; Antiparasitic agents; Antiprotozoal Agents - administration & dosage; Antiprotozoal Agents - adverse effects; Antiprotozoal Agents - therapeutic use; Biological and medical sciences; Child; Dosage; Dosage and administration; Drug Administration Schedule; Experimentation; Female; Fever; Humans; Infusions, Intravenous; Kala-azar; Leishmaniasis, Visceral - drug therapy; Lipids; Liposomes; Male; Medical cures; Medical sciences; Parasites; Pharmacology. Drug treatments; Pilot Projects; Recurrence; Relapse; Symptoms; Treatment Outcome; Tropical medicine; Visceral leishmaniasis; Asia; India; United Kingdom; Kinetoplastida; Human; Protozoa; Protozoal disease; Low dose; Leishmania donovani; Single dose; Kala azar; Leishmaniasis; Parasitosis; Infection; Chemotherapy; Treatment; Amphotericin B; Polyenic compound; Parasiticid; Daily dose

Objective To test short course, low dose liposomal amphotericin B as single or daily infusion treatment in Indian visceral leishmaniasis (kala-azar). Design Randomised, open label study. Setting Inpatient unit for leishmaniasis in Bihar, India. Participants 91 adults and children with splenic aspira...