The effect of host genetics on the gut microbiome

• Published in: Nature genetics Vol. 48; no. 11; pp. 1407 - 1412
• Main Authors: Bonder, Marc Jan, Kurilshikov, Alexander, Tigchelaar, Ettje F, Mujagic, Zlatan, Imhann, Floris, Vila, Arnau Vich, Deelen, Patrick, Vatanen, Tommi, Schirmer, Melanie, Smeekens, Sanne P, Zhernakova, Daria V, Jankipersadsing, Soesma A, Jaeger, Martin, Oosting, Marije, Cenit, Maria Carmen, Masclee, Ad A M, Swertz, Morris A, Li, Yang, Kumar, Vinod, Joosten, Leo, Harmsen, Hermie, Weersma, Rinse K, Franke, Lude, Hofker, Marten H, Xavier, Ramnik J, Jonkers, Daisy, Netea, Mihai G, Wijmenga, Cisca, Fu, Jingyuan, Zhernakova, Alexandra
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.11.2016; Nature Publishing Group
• Subjects: 45; 45/23; 45/43; 631/208/205/2138; 631/208/207; 631/208/325; Adolescent; Adult; Aged; Agriculture; Animal Genetics and Genomics; Animals; Archives & records; Bacteria; Biomedicine; Cancer Research; Cohort Studies; Disease; Female; Funding; Gastrointestinal Microbiome; Gene Function; Gene loci; Genetic aspects; Genetics; Genome, Human; Genome-Wide Association Study; Genomes; Genomics; Genotypes; Grants; Growth; Host-bacteria relationships; Human Genetics; Humans; Immunity - genetics; letter; Male; Metabolism; Mice; Microbiota (Symbiotic organisms); Middle Aged; Nutrition research; Polymorphism, Single Nucleotide; Properties; Studies; Taxonomy; Vocabularies & taxonomies; Young Adult

Alexandra Zhernakova, Jingyuan Fu, Cisca Wijmenga and colleagues perform genome-wide association analysis for microbiome characteristics in a cohort with fully sequenced metagenomes and detailed diet and lifestyle data. They find loci significantly associated with different microbial species, pathwa...