The effect of host genetics on the gut microbiome

Alexandra Zhernakova, Jingyuan Fu, Cisca Wijmenga and colleagues perform genome-wide association analysis for microbiome characteristics in a cohort with fully sequenced metagenomes and detailed diet and lifestyle data. They find loci significantly associated with different microbial species, pathwa...

Full description

Saved in:
Bibliographic Details
Published inNature genetics Vol. 48; no. 11; pp. 1407 - 1412
Main Authors Bonder, Marc Jan, Kurilshikov, Alexander, Tigchelaar, Ettje F, Mujagic, Zlatan, Imhann, Floris, Vila, Arnau Vich, Deelen, Patrick, Vatanen, Tommi, Schirmer, Melanie, Smeekens, Sanne P, Zhernakova, Daria V, Jankipersadsing, Soesma A, Jaeger, Martin, Oosting, Marije, Cenit, Maria Carmen, Masclee, Ad A M, Swertz, Morris A, Li, Yang, Kumar, Vinod, Joosten, Leo, Harmsen, Hermie, Weersma, Rinse K, Franke, Lude, Hofker, Marten H, Xavier, Ramnik J, Jonkers, Daisy, Netea, Mihai G, Wijmenga, Cisca, Fu, Jingyuan, Zhernakova, Alexandra
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.11.2016
Nature Publishing Group
Subjects
45
45/23
45/43
631/208/205/2138
631/208/207
631/208/325
Adolescent
Adult
Aged
Agriculture
Animal Genetics and Genomics
Animals
Archives & records
Bacteria
Biomedicine
Cancer Research
Cohort Studies
Disease
Female
Funding
Gastrointestinal Microbiome
Gene Function
Gene loci
Genetic aspects
Genetics
Genome, Human
Genome-Wide Association Study
Genomes
Genomics
Genotypes
Grants
Growth
Host-bacteria relationships
Human Genetics
Humans
Immunity - genetics
letter
Male
Metabolism
Mice
Microbiota (Symbiotic organisms)
Middle Aged
Nutrition research
Polymorphism, Single Nucleotide
Properties
Studies
Taxonomy
Vocabularies & taxonomies
Young Adult
Online AccessGet full text

Cover

Abstract Alexandra Zhernakova, Jingyuan Fu, Cisca Wijmenga and colleagues perform genome-wide association analysis for microbiome characteristics in a cohort with fully sequenced metagenomes and detailed diet and lifestyle data. They find loci significantly associated with different microbial species, pathways and genes and examine specific gene–diet interactions. The gut microbiome is affected by multiple factors, including genetics. In this study, we assessed the influence of host genetics on microbial species, pathways and gene ontology categories, on the basis of metagenomic sequencing in 1,514 subjects. In a genome-wide analysis, we identified associations of 9 loci with microbial taxonomies and 33 loci with microbial pathways and gene ontology terms at P < 5 × 10 −8 . Additionally, in a targeted analysis of regions involved in complex diseases, innate and adaptive immunity, or food preferences, 32 loci were identified at the suggestive level of P < 5 × 10 −6 . Most of our reported associations are new, including genome-wide significance for the C-type lectin molecules CLEC4F – CD207 at 2p13.3 and CLEC4A – FAM90A1 at 12p13. We also identified association of a functional LCT SNP with the Bifidobacterium genus ( P = 3.45 × 10 −8 ) and provide evidence of a gene–diet interaction in the regulation of Bifidobacterium abundance. Our results demonstrate the importance of understanding host–microbe interactions to gain better insight into human health.
AbstractList The gut microbiome is affected by multiple factors, including genetics. In this study, we assessed the influence of host genetics on microbial species, pathways and gene ontology categories, on the basis of metagenomic sequencing in 1,514 subjects. In a genome-wide analysis, we identified associations of 9 loci with microbial taxonomies and 33 loci with microbial pathways and gene ontology terms at P < 5 × 10^sup -8^. Additionally, in a targeted analysis of regions involved in complex diseases, innate and adaptive immunity, or food preferences, 32 loci were identified at the suggestive level of P < 5 × 10^sup -6^. Most of our reported associations are new, including genome-wide significance for the C-type lectin molecules CLEC4F-CD207 at 2p13.3 and CLEC4A-FAM90A1 at 12p13. We also identified association of a functional LCT SNP with the Bifidobacterium genus (P = 3.45 × 10^sup -8^) and provide evidence of a gene-diet interaction in the regulation of Bifidobacterium abundance. Our results demonstrate the importance of understanding host-microbe interactions to gain better insight into human health.
Alexandra Zhernakova, Jingyuan Fu, Cisca Wijmenga and colleagues perform genome-wide association analysis for microbiome characteristics in a cohort with fully sequenced metagenomes and detailed diet and lifestyle data. They find loci significantly associated with different microbial species, pathways and genes and examine specific gene–diet interactions. The gut microbiome is affected by multiple factors, including genetics. In this study, we assessed the influence of host genetics on microbial species, pathways and gene ontology categories, on the basis of metagenomic sequencing in 1,514 subjects. In a genome-wide analysis, we identified associations of 9 loci with microbial taxonomies and 33 loci with microbial pathways and gene ontology terms at P < 5 × 10 −8 . Additionally, in a targeted analysis of regions involved in complex diseases, innate and adaptive immunity, or food preferences, 32 loci were identified at the suggestive level of P < 5 × 10 −6 . Most of our reported associations are new, including genome-wide significance for the C-type lectin molecules CLEC4F – CD207 at 2p13.3 and CLEC4A – FAM90A1 at 12p13. We also identified association of a functional LCT SNP with the Bifidobacterium genus ( P = 3.45 × 10 −8 ) and provide evidence of a gene–diet interaction in the regulation of Bifidobacterium abundance. Our results demonstrate the importance of understanding host–microbe interactions to gain better insight into human health.
The gut microbiome is affected by multiple factors, including genetics. In this study, we assessed the influence of host genetics on microbial species, pathways and gene ontology categories, on the basis of metagenomic sequencing in 1,514 subjects. In a genome-wide analysis, we identified associations of 9 loci with microbial taxonomies and 33 loci with microbial pathways and gene ontology terms at P < 5 × 10-8. Additionally, in a targeted analysis of regions involved in complex diseases, innate and adaptive immunity, or food preferences, 32 loci were identified at the suggestive level of P < 5 × 10-6. Most of our reported associations are new, including genome-wide significance for the C-type lectin molecules CLEC4F-CD207 at 2p13.3 and CLEC4A-FAM90A1 at 12p13. We also identified association of a functional LCT SNP with the Bifidobacterium genus (P = 3.45 × 10-8) and provide evidence of a gene-diet interaction in the regulation of Bifidobacterium abundance. Our results demonstrate the importance of understanding host-microbe interactions to gain better insight into human health.
The gut microbiome is affected by multiple factors, including genetics. In this study, we assessed the influence of host genetics on microbial species, pathways and gene ontology categories, on the basis of metagenomic sequencing in 1,514 subjects. In a genome-wide analysis, we identified associations of 9 loci with microbial taxonomies and 33 loci with microbial pathways and gene ontology terms at P < 5 × 10 . Additionally, in a targeted analysis of regions involved in complex diseases, innate and adaptive immunity, or food preferences, 32 loci were identified at the suggestive level of P < 5 × 10 . Most of our reported associations are new, including genome-wide significance for the C-type lectin molecules CLEC4F-CD207 at 2p13.3 and CLEC4A-FAM90A1 at 12p13. We also identified association of a functional LCT SNP with the Bifidobacterium genus (P = 3.45 × 10 ) and provide evidence of a gene-diet interaction in the regulation of Bifidobacterium abundance. Our results demonstrate the importance of understanding host-microbe interactions to gain better insight into human health.
Audience Academic
Author Vila, Arnau Vich
Netea, Mihai G
Wijmenga, Cisca
Imhann, Floris
Kurilshikov, Alexander
Franke, Lude
Vatanen, Tommi
Harmsen, Hermie
Tigchelaar, Ettje F
Jaeger, Martin
Cenit, Maria Carmen
Masclee, Ad A M
Jonkers, Daisy
Bonder, Marc Jan
Fu, Jingyuan
Swertz, Morris A
Weersma, Rinse K
Smeekens, Sanne P
Joosten, Leo
Kumar, Vinod
Hofker, Marten H
Xavier, Ramnik J
Jankipersadsing, Soesma A
Deelen, Patrick
Schirmer, Melanie
Oosting, Marije
Zhernakova, Daria V
Li, Yang
Zhernakova, Alexandra
Mujagic, Zlatan
Author_xml – sequence: 1
  givenname: Marc Jan
  surname: Bonder
  fullname: Bonder, Marc Jan
  organization: Department of Genetics, University of Groningen, University Medical Center Groningen
– sequence: 2
  givenname: Alexander
  orcidid: 0000-0003-2541-5627
  surname: Kurilshikov
  fullname: Kurilshikov, Alexander
  organization: Department of Genetics, University of Groningen, University Medical Center Groningen, Institute of Chemical Biology and Fundamental Medicine SB RAS, Department of Natural Sciences, Novosibirsk State University
– sequence: 3
  givenname: Ettje F
  surname: Tigchelaar
  fullname: Tigchelaar, Ettje F
  organization: Department of Genetics, University of Groningen, University Medical Center Groningen, Top Institute Food and Nutrition
– sequence: 4
  givenname: Zlatan
  surname: Mujagic
  fullname: Mujagic, Zlatan
  organization: Top Institute Food and Nutrition, Division of Gastroenterology-Hepatology, Department of Internal Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center
– sequence: 5
  givenname: Floris
  surname: Imhann
  fullname: Imhann, Floris
  organization: Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen
– sequence: 6
  givenname: Arnau Vich
  surname: Vila
  fullname: Vila, Arnau Vich
  organization: Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen
– sequence: 7
  givenname: Patrick
  orcidid: 0000-0002-5654-3966
  surname: Deelen
  fullname: Deelen, Patrick
  organization: Department of Genetics, University of Groningen, University Medical Center Groningen, University of Groningen, University Medical Center Groningen, Genomics Coordination Center
– sequence: 8
  givenname: Tommi
  surname: Vatanen
  fullname: Vatanen, Tommi
  organization: Broad Institute of MIT and Harvard, Department of Computer Science, Aalto University School of Science
– sequence: 9
  givenname: Melanie
  surname: Schirmer
  fullname: Schirmer, Melanie
  organization: Broad Institute of MIT and Harvard, Department of Biostatistics, Harvard T.H. Chan School of Public Health
– sequence: 10
  givenname: Sanne P
  surname: Smeekens
  fullname: Smeekens, Sanne P
  organization: Department of Internal Medicine, Radboud University Medical Center, Radboud Center of Infectious Diseases, Radboud University Medical Center
– sequence: 11
  givenname: Daria V
  surname: Zhernakova
  fullname: Zhernakova, Daria V
  organization: Department of Genetics, University of Groningen, University Medical Center Groningen
– sequence: 12
  givenname: Soesma A
  orcidid: 0000-0001-9225-9236
  surname: Jankipersadsing
  fullname: Jankipersadsing, Soesma A
  organization: Department of Genetics, University of Groningen, University Medical Center Groningen, Department of Pediatrics, University of Groningen, University Medical Center Groningen
– sequence: 13
  givenname: Martin
  surname: Jaeger
  fullname: Jaeger, Martin
  organization: Department of Internal Medicine, Radboud University Medical Center, Radboud Center of Infectious Diseases, Radboud University Medical Center
– sequence: 14
  givenname: Marije
  surname: Oosting
  fullname: Oosting, Marije
  organization: Department of Internal Medicine, Radboud University Medical Center, Radboud Center of Infectious Diseases, Radboud University Medical Center
– sequence: 15
  givenname: Maria Carmen
  surname: Cenit
  fullname: Cenit, Maria Carmen
  organization: Department of Genetics, University of Groningen, University Medical Center Groningen, Present address: Department of Pediatrics, Dr. Peset University Hospital, Valencia, Spain
– sequence: 16
  givenname: Ad A M
  surname: Masclee
  fullname: Masclee, Ad A M
  organization: Division of Gastroenterology-Hepatology, Department of Internal Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center
– sequence: 17
  givenname: Morris A
  surname: Swertz
  fullname: Swertz, Morris A
  organization: Department of Genetics, University of Groningen, University Medical Center Groningen, University of Groningen, University Medical Center Groningen, Genomics Coordination Center
– sequence: 18
  givenname: Yang
  surname: Li
  fullname: Li, Yang
  organization: Department of Genetics, University of Groningen, University Medical Center Groningen
– sequence: 19
  givenname: Vinod
  surname: Kumar
  fullname: Kumar, Vinod
  organization: Department of Genetics, University of Groningen, University Medical Center Groningen
– sequence: 20
  givenname: Leo
  surname: Joosten
  fullname: Joosten, Leo
  organization: Department of Internal Medicine, Radboud University Medical Center, Radboud Center of Infectious Diseases, Radboud University Medical Center
– sequence: 21
  givenname: Hermie
  surname: Harmsen
  fullname: Harmsen, Hermie
  organization: Department of Medical Microbiology, University of Groningen, University Medical Center Groningen
– sequence: 22
  givenname: Rinse K
  surname: Weersma
  fullname: Weersma, Rinse K
  organization: Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen
– sequence: 23
  givenname: Lude
  orcidid: 0000-0002-5159-8802
  surname: Franke
  fullname: Franke, Lude
  organization: Department of Genetics, University of Groningen, University Medical Center Groningen
– sequence: 24
  givenname: Marten H
  surname: Hofker
  fullname: Hofker, Marten H
  organization: Department of Pediatrics, University of Groningen, University Medical Center Groningen
– sequence: 25
  givenname: Ramnik J
  surname: Xavier
  fullname: Xavier, Ramnik J
  organization: Broad Institute of MIT and Harvard, Center for Computational and Integrative Biology, Massachusetts General Hospital, Gastrointestinal Unit, Massachusetts General Hospital, Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital
– sequence: 26
  givenname: Daisy
  surname: Jonkers
  fullname: Jonkers, Daisy
  organization: Division of Gastroenterology-Hepatology, Department of Internal Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center
– sequence: 27
  givenname: Mihai G
  surname: Netea
  fullname: Netea, Mihai G
  organization: Department of Internal Medicine, Radboud University Medical Center, Radboud Center of Infectious Diseases, Radboud University Medical Center
– sequence: 28
  givenname: Cisca
  surname: Wijmenga
  fullname: Wijmenga, Cisca
  email: c.wijmenga@umcg.nl
  organization: Department of Genetics, University of Groningen, University Medical Center Groningen
– sequence: 29
  givenname: Jingyuan
  surname: Fu
  fullname: Fu, Jingyuan
  email: j.fu@umcg.nl
  organization: Department of Genetics, University of Groningen, University Medical Center Groningen, Department of Pediatrics, University of Groningen, University Medical Center Groningen
– sequence: 30
  givenname: Alexandra
  orcidid: 0000-0002-4574-0841
  surname: Zhernakova
  fullname: Zhernakova, Alexandra
  email: a.zhernakova@umcg.nl
  organization: Department of Genetics, University of Groningen, University Medical Center Groningen, Top Institute Food and Nutrition
BackLink https://www.ncbi.nlm.nih.gov/pubmed/27694959$$D View this record in MEDLINE/PubMed
BookMark eNqNksFO3DAQhq0KVNgt6htUkXqBQxZP7IydI0KFIiEhAeVqJd5JCNrYNHYk-vY4AkS36gH5MJbnm5H_f2bBdpx3xNhX4CvgQh-7biUQxSe2D6XEHBTonXTnCLnkAvfYIoQHzkFKrj-zvUJhJauy2mdwe08ZtS3ZmPk2u_chZh05ir0NmXdZTOluitnQ29E3vR_oC9tt602gg9e4ZL_Oftye_swvr84vTk8u804qEXNslK3LdQNKQoENYKFUKa1CjS1XAqo1Vci1BK7IagQuG1kQl7YQJdRYiSU7fOn7OPrfE4Vohj5Y2mxqR34KBrQoRRIhZvT7P-iDn0aXfjdTCdBQqneqqzdketf6ONZ2bmpOJGrOC0SeqNV_qHTWlDxIrrd9et8qONoqSEykp9jVUwjm4ub64-zV3Tb77VXU1Ay0No9jP9TjH_M2u3eDQkq5jsa_VHMzr4VxnZnXQjwDOAShQw
Cites_doi 10.1038/nmeth.3589
10.1038/nature12828
10.1111/j.1440-1827.2011.02646.x
10.1038/nm956
10.1136/gutjnl-2014-307289
10.1016/j.coi.2014.12.002
10.1101/gr.194118.115
10.1038/nmeth.2307
10.1186/1756-0500-7-901
10.2337/diabetes.51.12.3586
10.1097/01.MIB.0000480097.23732.5e
10.1093/hmg/ddq560
10.1038/ng.2694
10.1371/journal.pone.0064683
10.1056/NEJMoa0907206
10.1038/nm.4140
10.1038/nature15393
10.1038/ismej.2012.104
10.1093/ajcn/87.4.993
10.1136/gutjnl-2015-310328
10.1093/bioinformatics/bts180
10.1038/nm.4102
10.1093/hmg/ddn072
10.1126/science.1221789
10.1126/science.1262110
10.1186/s13059-015-0759-1
10.1016/j.cub.2010.04.041
10.1016/j.cell.2016.04.007
10.1111/apt.13552
10.1093/nar/gkr1048
10.1136/gutjnl-2012-303786
10.1038/nature11019
10.1186/s13059-014-0552-6
10.1038/nature11550
10.1007/s10735-013-9504-9
10.1016/j.phrs.2012.10.020
10.2337/db11-0415
10.1186/1471-2148-11-202
10.1038/ni1417
10.1186/s13073-014-0107-1
10.1186/gb-2012-13-9-r79
10.1038/srep12955
10.1038/nature12820
10.1038/nature11582
10.1038/nature14177
10.1074/jbc.M512905200
10.1111/apt.12829
10.1007/s00125-003-1323-1
10.1016/j.cell.2014.09.053
10.1136/bmjopen-2014-006772
10.1534/g3.111.001198
10.1146/annurev-statistics-022513-115654
10.1038/ng.2756
10.1016/j.cmet.2015.07.026
10.1128/IAI.02213-14
10.1146/annurev-immunol-032713-120238
10.1161/CIRCRESAHA.115.306807
10.1111/j.1420-9101.2005.00917.x
10.1016/j.chom.2014.02.005
10.1371/journal.pone.0066934
10.1093/bioinformatics/btu170
10.1093/hmg/ddv028
10.1053/j.gastro.2013.10.021
10.1038/ejhg.2014.19
10.3389/fimmu.2014.00342
10.1016/j.bbagen.2005.02.003
10.1194/jlr.R800058-JLR200
10.1016/j.chom.2016.04.017
10.1371/journal.pone.0039191
10.1158/1078-0432.CCR-13-2863
10.1038/ncomms8113
10.1016/S0021-9150(01)00447-6
10.1089/ars.2012.4701
10.1371/journal.pone.0140301
10.1038/ng1946
10.1017/S0007114511000067
10.1086/520705
10.1126/science.aad3369
10.1016/j.cmet.2012.12.007
10.1136/gutjnl-2015-310376
10.1038/ncomms3462
10.1038/nature16937
10.1186/1475-2891-12-75
ContentType Journal Article
Copyright Springer Nature America, Inc. 2016
COPYRIGHT 2016 Nature Publishing Group
Copyright Nature Publishing Group Nov 2016
Copyright_xml – notice: Springer Nature America, Inc. 2016
– notice: COPYRIGHT 2016 Nature Publishing Group
– notice: Copyright Nature Publishing Group Nov 2016
DBID CGR
CUY
CVF
ECM
EIF
NPM
IOV
ISR
3V.
7QL
7QP
7QR
7SS
7T7
7TK
7TM
7U9
7X7
7XB
88A
88E
8AO
8C1
8FD
8FE
8FH
8FI
8FJ
8FK
8G5
ABUWG
AEUYN
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
C1K
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
GUQSH
H94
HCIFZ
K9.
LK8
M0S
M1P
M2O
M7N
M7P
MBDVC
P64
PHGZM
PHGZT
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
Q9U
RC3
7X8
DOI 10.1038/ng.3663
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
Opposing Viewpoints in Context
Gale In Context: Science
ProQuest Central (Corporate)
Bacteriology Abstracts (Microbiology B)
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Entomology Abstracts (Full archive)
Industrial and Applied Microbiology Abstracts (Microbiology A)
Neurosciences Abstracts
Nucleic Acids Abstracts
Virology and AIDS Abstracts
ProQuest Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Biology Database (Alumni Edition)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Public Health Database
Technology Research Database
ProQuest SciTech Collection
ProQuest Natural Science Collection
ProQuest Hospital Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Research Library
ProQuest Central (Alumni)
ProQuest One Sustainability
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Database
ProQuest Central
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One Community College
ProQuest Central
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
ProQuest Research Library
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
ProQuest Health & Medical Collection
Proquest Medical Database
Research Library
Algology Mycology and Protozoology Abstracts (Microbiology C)
Biological Science Database
Research Library (Corporate)
Biotechnology and BioEngineering Abstracts
ProQuest Central Premium
ProQuest One Academic
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest Central Basic
Genetics Abstracts
MEDLINE - Academic
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Research Library Prep
ProQuest Central Student
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
ProQuest Central China
Environmental Sciences and Pollution Management
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
Health Research Premium Collection
Natural Science Collection
Health & Medical Research Collection
Biological Science Collection
Chemoreception Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
ProQuest Central (New)
ProQuest Medical Library (Alumni)
Virology and AIDS Abstracts
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Neurosciences Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Entomology Abstracts
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
ProQuest One Academic (New)
Technology Research Database
ProQuest One Academic Middle East (New)
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
Research Library (Alumni Edition)
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Biology Journals (Alumni Edition)
ProQuest Central
ProQuest Health & Medical Research Collection
Genetics Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
Algology Mycology and Protozoology Abstracts (Microbiology C)
AIDS and Cancer Research Abstracts
ProQuest Research Library
ProQuest Public Health
ProQuest Central Basic
ProQuest SciTech Collection
ProQuest Medical Library
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList Research Library Prep

MEDLINE - Academic
MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Agriculture
Biology
EISSN 1546-1718
EndPage 1412
ExternalDocumentID 4233172621
A468002660
27694959
10_1038_ng_3663
Genre Research Support, Non-U.S. Gov't
Journal Article
Feature
GroupedDBID ---
-DZ
-~X
.55
.GJ
0R~
123
29M
2FS
36B
39C
3O-
3V.
4.4
53G
5BI
5M7
5RE
5S5
70F
7X7
85S
88A
88E
8AO
8C1
8FE
8FH
8FI
8FJ
8G5
8R4
8R5
AAEEF
AAHBH
AARCD
AAYOK
AAYZH
AAZLF
ABAWZ
ABCQX
ABDBF
ABDPE
ABEFU
ABJNI
ABLJU
ABOCM
ABTAH
ABUWG
ACBWK
ACGFO
ACGFS
ACIWK
ACMJI
ACNCT
ACPRK
ACUHS
ADBBV
ADFRT
AENEX
AEUYN
AFBBN
AFFNX
AFKRA
AFRAH
AFSHS
AGAYW
AGCDD
AGHTU
AHBCP
AHMBA
AHOSX
AHSBF
AIBTJ
ALFFA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMTXH
ARMCB
ASPBG
AVWKF
AXYYD
AZFZN
AZQEC
B0M
BBNVY
BENPR
BHPHI
BKKNO
BPHCQ
BVXVI
CCPQU
CS3
DB5
DU5
DWQXO
EAD
EAP
EBC
EBD
EBS
EE.
EJD
EMB
EMK
EMOBN
EPL
ESX
EXGXG
F5P
FEDTE
FQGFK
FSGXE
FYUFA
GNUQQ
GUQSH
GX1
HCIFZ
HMCUK
HVGLF
HZ~
IAO
IH2
IHR
INH
INR
IOV
ISR
ITC
L7B
LGEZI
LK8
LOTEE
M0L
M1P
M2O
M7P
MVM
N9A
NADUK
NNMJJ
NXXTH
ODYON
P2P
PKN
PQQKQ
PROAC
PSQYO
Q2X
RIG
RNS
RNT
RNTTT
RVV
SHXYY
SIXXV
SJN
SNYQT
SOJ
SV3
TAOOD
TBHMF
TDRGL
TN5
TSG
TUS
UKHRP
VQA
X7M
XJT
XOL
Y6R
YHZ
ZGI
ZXP
ZY4
~8M
~KM
AETEA
AFANA
ALPWD
CGR
CUY
CVF
ECM
EIF
NFIDA
NPM
PHGZT
ABFSG
ACMFV
ACSTC
ATHPR
PHGZM
AEIIB
PMFND
7QL
7QP
7QR
7SS
7T7
7TK
7TM
7U9
7XB
8FD
8FK
C1K
FR3
H94
K9.
M7N
MBDVC
P64
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQUKI
PRINS
Q9U
RC3
7X8
ID FETCH-LOGICAL-g473t-6b7ca5db174126b1627754c7686f07319de96084107ec86104b42e04c2351a693
IEDL.DBID 7X7
ISSN 1061-4036
IngestDate Thu Jul 10 22:00:04 EDT 2025
Fri Jul 25 08:59:54 EDT 2025
Tue Jun 17 21:31:49 EDT 2025
Tue Jun 10 20:39:38 EDT 2025
Fri Jun 27 04:37:36 EDT 2025
Fri Jun 27 05:02:48 EDT 2025
Thu Apr 03 07:03:10 EDT 2025
Fri Feb 21 02:39:09 EST 2025
IsPeerReviewed true
IsScholarly true
Issue 11
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-g473t-6b7ca5db174126b1627754c7686f07319de96084107ec86104b42e04c2351a693
Notes SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 14
ObjectType-Article-1
ObjectType-Feature-2
content type line 23
ORCID 0000-0003-2541-5627
0000-0002-5654-3966
0000-0001-9225-9236
0000-0002-4574-0841
0000-0002-5159-8802
PMID 27694959
PQID 1833938157
PQPubID 33429
PageCount 6
ParticipantIDs proquest_miscellaneous_1835349539
proquest_journals_1833938157
gale_infotracmisc_A468002660
gale_infotracacademiconefile_A468002660
gale_incontextgauss_ISR_A468002660
gale_incontextgauss_IOV_A468002660
pubmed_primary_27694959
springer_journals_10_1038_ng_3663
PublicationCentury 2000
PublicationDate 2016-11-01
PublicationDateYYYYMMDD 2016-11-01
PublicationDate_xml – month: 11
  year: 2016
  text: 2016-11-01
  day: 01
PublicationDecade 2010
PublicationPlace New York
PublicationPlace_xml – name: New York
– name: United States
PublicationTitle Nature genetics
PublicationTitleAbbrev Nat Genet
PublicationTitleAlternate Nat Genet
PublicationYear 2016
Publisher Nature Publishing Group US
Nature Publishing Group
Publisher_xml – name: Nature Publishing Group US
– name: Nature Publishing Group
References Imhann (CR2) 2015; 65
Tigchelaar (CR18) 2015; 5
Hromatka (CR24) 2015; 24
Williams (CR26) 2014; 506
Dambuza, Brown (CR62) 2015; 32
Netea (CR19) 2016; 22
Huuskonen, Olkkonen, Jauhiainen, Ehnholm (CR48) 2001; 155
Hao (CR53) 2012; 485
Farin (CR54) 2016; 530
Caballero, Pamer (CR58) 2015; 33
Torres (CR23) 2016; 43
Kaplan (CR35) 2011; 20
Jia (CR76) 2013; 8
Robinson, Sancho, Slack, LeibundGut-Landmann, Reis e Sousa (CR84) 2006; 7
Deelen (CR72) 2014; 7
Lozupone, Stombaugh, Gordon, Jansson, Knight (CR40) 2012; 489
Strawbridge (CR37) 2011; 60
Khan, Browne, van Dijl, Harmsen (CR38) 2012; 17
Tyler (CR29) 2013; 8
Martínez (CR28) 2013; 7
Locke (CR25) 2015; 518
Truong (CR78) 2015; 12
Bunge, Willis, Walsh (CR57) 2014; 1
Glocker (CR46) 2009; 361
Gevers (CR42) 2014; 15
Singh (CR59) 2015; 6
Sadaghian Sadabad (CR61) 2014; 64
Streppel (CR67) 2013; 12
Bolger, Lohse, Usadel (CR77) 2014; 30
Jostins (CR15) 2012; 491
Lamas (CR17) 2016; 22
Delaneau, Zagury, Marchini (CR73) 2013; 10
Landy (CR30) 2015; 5
Reikine, Nguyen, Modis (CR85) 2014; 5
Hevener (CR50) 2003; 9
Auton (CR71) 2015; 526
CR88
Kalabis, Rosenberg, Podolsky (CR31) 2006; 281
Nguyen (CR60) 2014; 146
Dimmer (CR79) 2012; 40
CR83
CR80
Westra (CR82) 2013; 45
Parks (CR13) 2013; 17
Goodrich (CR9) 2016; 19
Org (CR7) 2015; 25
Vatanen (CR81) 2016; 165
Tigchelaar (CR1) 2015; 65
Leamy (CR8) 2014; 15
Yahiro (CR44) 2014; 82
Casals (CR56) 2011; 11
Koren, Reem, Kimchi (CR45) 2010; 20
Galeone, Colucci, D'Erme, Moretti, Lotti (CR47) 2012; 2012
Tishkoff (CR65) 2007; 39
Getz, Reardon (CR49) 2009; 50
Ardlie (CR87) 2015; 348
Zhernakova (CR3) 2016; 352
Shah (CR70) 2012; 28
Bønnelykke (CR41) 2013; 45
Scott, Gratz, Sheridan, Flint, Duncan (CR5) 2013; 69
Davenport (CR11) 2015; 10
Caesar, Tremaroli, Kovatcheva-Datchary, Cani, Bäckhed (CR43) 2015; 22
Liu (CR36) 2008; 17
Zhou (CR55) 2013; 44
Klingberg (CR34) 2008; 87
Doney (CR52) 2004; 47
Hegele, Cao, Frankowski, Mathews, Leff (CR51) 2002; 51
Blekhman (CR10) 2015; 16
Morgan (CR39) 2012; 13
Troelsen (CR66) 2005; 1723
Srinivas (CR12) 2013; 4
Bae (CR32) 2014; 20
Juste (CR21) 2014; 63
Iliev (CR63) 2012; 336
CR69
Whitlock (CR86) 2005; 18
Liu (CR22) 2016; 22
Fu (CR27) 2015; 117
Siebelink, Geelen, de Vries (CR68) 2011; 106
Howie, Marchini, Stephens (CR74) 2011; 1
McKnite (CR14) 2012; 7
Goodrich (CR6) 2014; 159
Mujagic (CR20) 2014; 40
Lee (CR33) 2011; 61
Enattah (CR64) 2007; 81
Knights (CR16) 2014; 6
David (CR4) 2014; 505
Deelen (CR75) 2014; 22
References_xml – volume: 12
  start-page: 902
  year: 2015
  end-page: 903
  ident: CR78
  article-title: MetaPhlAn2 for enhanced metagenomic taxonomic profiling
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.3589
– volume: 506
  start-page: 97
  year: 2014
  end-page: 101
  ident: CR26
  article-title: Sequence variants in are a common risk factor for type 2 diabetes in Mexico
  publication-title: Nature
  doi: 10.1038/nature12828
– volume: 2012
  start-page: 595380
  year: 2012
  ident: CR47
  article-title: Potential infectious etiology of Behçet's disease
  publication-title: Patholog. Res. Int.
– volume: 61
  start-page: 210
  year: 2011
  end-page: 220
  ident: CR33
  article-title: Expression of KITENIN in human colorectal cancer and its relation to tumor behavior and progression
  publication-title: Pathol. Int.
  doi: 10.1111/j.1440-1827.2011.02646.x
– volume: 9
  start-page: 1491
  year: 2003
  end-page: 1497
  ident: CR50
  article-title: Muscle-specific deletion causes insulin resistance
  publication-title: Nat. Med.
  doi: 10.1038/nm956
– volume: 64
  start-page: 1546
  year: 2014
  end-page: 1552
  ident: CR61
  article-title: The -T300A allele impairs clearance of pathosymbionts in the inflamed ileal mucosa of Crohn's disease patients
  publication-title: Gut
  doi: 10.1136/gutjnl-2014-307289
– volume: 32
  start-page: 21
  year: 2015
  end-page: 27
  ident: CR62
  article-title: C-type lectins in immunity: recent developments
  publication-title: Curr. Opin. Immunol.
  doi: 10.1016/j.coi.2014.12.002
– volume: 25
  start-page: 1558
  year: 2015
  end-page: 1569
  ident: CR7
  article-title: Genetic and environmental control of host–gut microbiota interactions
  publication-title: Genome Res.
  doi: 10.1101/gr.194118.115
– volume: 10
  start-page: 5
  year: 2013
  end-page: 6
  ident: CR73
  article-title: Improved whole-chromosome phasing for disease and population genetic studies
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.2307
– volume: 7
  start-page: 901
  year: 2014
  ident: CR72
  article-title: Genotype harmonizer: automatic strand alignment and format conversion for genotype data integration
  publication-title: BMC Res. Notes
  doi: 10.1186/1756-0500-7-901
– volume: 51
  start-page: 3586
  year: 2002
  end-page: 3590
  ident: CR51
  article-title: PPARG F388L, a transactivation-deficient mutant, in familial partial lipodystrophy
  publication-title: Diabetes
  doi: 10.2337/diabetes.51.12.3586
– ident: CR80
– volume: 22
  start-page: S4
  issue: Suppl. 1
  year: 2016
  ident: CR22
  article-title: O-011 Paneth cell phenotypes define a subtype of pediatric Crohn's disease through alterations in host–microbial interactions
  publication-title: Inflamm. Bowel Dis.
  doi: 10.1097/01.MIB.0000480097.23732.5e
– volume: 20
  start-page: 1241
  year: 2011
  end-page: 1251
  ident: CR35
  article-title: A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddq560
– volume: 45
  start-page: 902
  year: 2013
  end-page: 906
  ident: CR41
  article-title: Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization
  publication-title: Nat. Genet.
  doi: 10.1038/ng.2694
– volume: 8
  start-page: e64683
  year: 2013
  ident: CR76
  article-title: Imputing amino acid polymorphisms in human leukocyte antigens
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0064683
– volume: 361
  start-page: 2033
  year: 2009
  end-page: 2045
  ident: CR46
  article-title: Inflammatory bowel disease and mutations affecting the interleukin-10 receptor
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa0907206
– volume: 22
  start-page: 831
  year: 2016
  end-page: 833
  ident: CR19
  article-title: Understanding human immune function using the resources from the Human Functional Genomics Project
  publication-title: Nat. Med.
  doi: 10.1038/nm.4140
– volume: 526
  start-page: 68
  year: 2015
  end-page: 74
  ident: CR71
  article-title: A global reference for human genetic variation
  publication-title: Nature
  doi: 10.1038/nature15393
– volume: 7
  start-page: 269
  year: 2013
  end-page: 280
  ident: CR28
  article-title: Gut microbiome composition is linked to whole grain–induced immunological improvements
  publication-title: ISME J.
  doi: 10.1038/ismej.2012.104
– volume: 87
  start-page: 993
  year: 2008
  end-page: 1001
  ident: CR34
  article-title: Inverse relation between dietary intake of naturally occurring plant sterols and serum cholesterol in northern Sweden
  publication-title: Am. J. Clin. Nutr.
  doi: 10.1093/ajcn/87.4.993
– volume: 65
  start-page: 540
  year: 2015
  end-page: 542
  ident: CR1
  article-title: Gut microbiota composition associated with stool consistency
  publication-title: Gut
  doi: 10.1136/gutjnl-2015-310328
– volume: 28
  start-page: 1598
  year: 2012
  end-page: 1603
  ident: CR70
  article-title: optiCall: a robust genotype-calling algorithm for rare, low-frequency and common variants
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/bts180
– volume: 22
  start-page: 598
  year: 2016
  end-page: 605
  ident: CR17
  article-title: CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands
  publication-title: Nat. Med.
  doi: 10.1038/nm.4102
– volume: 17
  start-page: 1803
  year: 2008
  end-page: 1813
  ident: CR36
  article-title: Genome-wide association scans identified as a novel gene for obesity
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddn072
– volume: 336
  start-page: 1314
  year: 2012
  end-page: 1317
  ident: CR63
  article-title: D. . Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis
  publication-title: Science
  doi: 10.1126/science.1221789
– volume: 348
  start-page: 648
  year: 2015
  end-page: 660
  ident: CR87
  article-title: The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans
  publication-title: Science
  doi: 10.1126/science.1262110
– volume: 16
  start-page: 191
  year: 2015
  ident: CR10
  article-title: Host genetic variation impacts microbiome composition across human body sites
  publication-title: Genome Biol.
  doi: 10.1186/s13059-015-0759-1
– volume: 20
  start-page: 1093
  year: 2010
  end-page: 1098
  ident: CR45
  article-title: DAP1, a novel substrate of mTOR, negatively regulates autophagy
  publication-title: Curr. Biol.
  doi: 10.1016/j.cub.2010.04.041
– volume: 165
  start-page: 842
  year: 2016
  end-page: 853
  ident: CR81
  article-title: Variation in microbiome LPS immunogenicity contributes to autoimmunity in humans
  publication-title: Cell
  doi: 10.1016/j.cell.2016.04.007
– volume: 43
  start-page: 790
  year: 2016
  end-page: 801
  ident: CR23
  article-title: The features of mucosa-associated microbiota in primary sclerosing cholangitis
  publication-title: Aliment. Pharmacol. Ther.
  doi: 10.1111/apt.13552
– ident: CR88
– volume: 40
  start-page: D565
  year: 2012
  end-page: D570
  ident: CR79
  article-title: The UniProt-GO Annotation database in 2011
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkr1048
– volume: 63
  start-page: 1566
  year: 2014
  end-page: 1577
  ident: CR21
  article-title: Bacterial protein signals are associated with Crohn's disease
  publication-title: Gut
  doi: 10.1136/gutjnl-2012-303786
– volume: 485
  start-page: 195
  year: 2012
  end-page: 200
  ident: CR53
  article-title: ZNRF3 promotes Wnt receptor turnover in an R-spondin–sensitive manner
  publication-title: Nature
  doi: 10.1038/nature11019
– volume: 15
  start-page: 552
  year: 2014
  ident: CR8
  article-title: Host genetics and diet, but not immunoglobulin A expression, converge to shape compositional features of the gut microbiome in an advanced intercross population of mice
  publication-title: Genome Biol.
  doi: 10.1186/s13059-014-0552-6
– volume: 489
  start-page: 220
  year: 2012
  end-page: 230
  ident: CR40
  article-title: Diversity, stability and resilience of the human gut microbiota
  publication-title: Nature
  doi: 10.1038/nature11550
– volume: 44
  start-page: 555
  year: 2013
  end-page: 563
  ident: CR55
  article-title: ZNRF3 acts as a tumour suppressor by the Wnt signalling pathway in human gastric adenocarcinoma
  publication-title: J. Mol. Histol.
  doi: 10.1007/s10735-013-9504-9
– volume: 69
  start-page: 52
  year: 2013
  end-page: 60
  ident: CR5
  article-title: The influence of diet on the gut microbiota
  publication-title: Pharmacol. Res.
  doi: 10.1016/j.phrs.2012.10.020
– volume: 60
  start-page: 2624
  year: 2011
  end-page: 2634
  ident: CR37
  article-title: Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes
  publication-title: Diabetes
  doi: 10.2337/db11-0415
– volume: 11
  start-page: 202
  year: 2011
  ident: CR56
  article-title: Genetic adaptation of the antibacterial human innate immunity network
  publication-title: BMC Evol. Biol.
  doi: 10.1186/1471-2148-11-202
– volume: 7
  start-page: 1258
  year: 2006
  end-page: 1265
  ident: CR84
  article-title: Myeloid C-type lectins in innate immunity
  publication-title: Nat. Immunol.
  doi: 10.1038/ni1417
– volume: 6
  start-page: 107
  year: 2014
  ident: CR16
  article-title: Complex host genetics influence the microbiome in inflammatory bowel disease
  publication-title: Genome Med.
  doi: 10.1186/s13073-014-0107-1
– volume: 13
  start-page: R79
  year: 2012
  ident: CR39
  article-title: Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment
  publication-title: Genome Biol.
  doi: 10.1186/gb-2012-13-9-r79
– volume: 5
  start-page: 12955
  year: 2015
  ident: CR30
  article-title: Variable alterations of the microbiota, without metabolic or immunological change, following faecal microbiota transplantation in patients with chronic pouchitis
  publication-title: Sci. Rep.
  doi: 10.1038/srep12955
– volume: 505
  start-page: 559
  year: 2014
  end-page: 563
  ident: CR4
  article-title: Diet rapidly and reproducibly alters the human gut microbiome
  publication-title: Nature
  doi: 10.1038/nature12820
– volume: 491
  start-page: 119
  year: 2012
  end-page: 124
  ident: CR15
  article-title: Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease
  publication-title: Nature
  doi: 10.1038/nature11582
– volume: 518
  start-page: 197
  year: 2015
  end-page: 206
  ident: CR25
  article-title: Genetic studies of body mass index yield new insights for obesity biology
  publication-title: Nature
  doi: 10.1038/nature14177
– volume: 281
  start-page: 6434
  year: 2006
  end-page: 6441
  ident: CR31
  article-title: Vangl1 protein acts as a downstream effector of intestinal trefoil factor (ITF)/TFF3 signaling and regulates wound healing of intestinal epithelium
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M512905200
– volume: 40
  start-page: 288
  year: 2014
  end-page: 297
  ident: CR20
  article-title: Small intestinal permeability is increased in diarrhoea predominant IBS, while alterations in gastroduodenal permeability in all IBS subtypes are largely attributable to confounders
  publication-title: Aliment. Pharmacol. Ther.
  doi: 10.1111/apt.12829
– volume: 47
  start-page: 555
  year: 2004
  end-page: 558
  ident: CR52
  article-title: Association of the Pro12Ala and C1431T variants of and their haplotypes with susceptibility to type 2 diabetes
  publication-title: Diabetologia
  doi: 10.1007/s00125-003-1323-1
– volume: 159
  start-page: 789
  year: 2014
  end-page: 799
  ident: CR6
  article-title: Human genetics shape the gut microbiome
  publication-title: Cell
  doi: 10.1016/j.cell.2014.09.053
– volume: 5
  start-page: e006772
  year: 2015
  ident: CR18
  article-title: Cohort profile: LifeLines DEEP, a prospective, general population cohort study in the northern Netherlands: study design and baseline characteristics
  publication-title: BMJ Open
  doi: 10.1136/bmjopen-2014-006772
– volume: 1
  start-page: 457
  year: 2011
  end-page: 470
  ident: CR74
  article-title: Genotype imputation with thousands of genomes
  publication-title: G3 (Bethesda)
  doi: 10.1534/g3.111.001198
– volume: 1
  start-page: 427
  year: 2014
  end-page: 445
  ident: CR57
  article-title: Estimating the number of species in microbial diversity studies
  publication-title: Annu. Rev. Stat. Appl.
  doi: 10.1146/annurev-statistics-022513-115654
– volume: 45
  start-page: 1238
  year: 2013
  end-page: 1243
  ident: CR82
  article-title: Systematic identification of trans eQTLs as putative drivers of known disease associations
  publication-title: Nat. Genet.
  doi: 10.1038/ng.2756
– volume: 22
  start-page: 658
  year: 2015
  end-page: 668
  ident: CR43
  article-title: Crosstalk between gut microbiota and dietary lipids aggravates WAT inflammation through TLR signaling
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2015.07.026
– volume: 82
  start-page: 4899
  year: 2014
  end-page: 4908
  ident: CR44
  article-title: DAP1, a negative regulator of autophagy, controls SubAB-mediated apoptosis and autophagy
  publication-title: Infect. Immun.
  doi: 10.1128/IAI.02213-14
– volume: 33
  start-page: 227
  year: 2015
  end-page: 256
  ident: CR58
  article-title: Microbiota-mediated inflammation and antimicrobial defense in the intestine
  publication-title: Annu. Rev. Immunol.
  doi: 10.1146/annurev-immunol-032713-120238
– volume: 117
  start-page: 817
  year: 2015
  end-page: 824
  ident: CR27
  article-title: The gut microbiome contributes to a substantial proportion of the variation in blood lipids
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.115.306807
– volume: 18
  start-page: 1368
  year: 2005
  end-page: 1373
  ident: CR86
  article-title: Combining probability from independent tests: the weighted -method is superior to Fisher's approach
  publication-title: J. Evol. Biol.
  doi: 10.1111/j.1420-9101.2005.00917.x
– volume: 15
  start-page: 382
  year: 2014
  end-page: 392
  ident: CR42
  article-title: The treatment-naive microbiome in new-onset Crohn's disease
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2014.02.005
– volume: 8
  start-page: e66934
  year: 2013
  ident: CR29
  article-title: Characterization of the gut-associated microbiome in inflammatory pouch complications following ileal pouch-anal anastomosis
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0066934
– volume: 30
  start-page: 2114
  year: 2014
  end-page: 2120
  ident: CR77
  article-title: Trimmomatic: a flexible trimmer for Illumina sequence data
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btu170
– volume: 24
  start-page: 2700
  year: 2015
  end-page: 2708
  ident: CR24
  article-title: Genetic variants associated with motion sickness point to roles for inner ear development, neurological processes and glucose homeostasis
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddv028
– volume: 146
  start-page: 508
  year: 2014
  end-page: 519
  ident: CR60
  article-title: Crohn's disease–associated adherent invasive modulate levels of microRNAs in intestinal epithelial cells to reduce autophagy
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2013.10.021
– volume: 22
  start-page: 1321
  year: 2014
  end-page: 1326
  ident: CR75
  article-title: Improved imputation quality of low-frequency and rare variants in European samples using the 'Genome of The Netherlands'
  publication-title: Eur. J. Hum. Genet.
  doi: 10.1038/ejhg.2014.19
– volume: 5
  start-page: 342
  year: 2014
  ident: CR85
  article-title: Pattern recognition and signaling mechanisms of RIG-I and MDA5
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2014.00342
– volume: 1723
  start-page: 19
  year: 2005
  end-page: 32
  ident: CR66
  article-title: Adult-type hypolactasia and regulation of lactase expression
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/j.bbagen.2005.02.003
– volume: 50
  start-page: S156
  issue: Suppl.
  year: 2009
  end-page: S161
  ident: CR49
  article-title: Apoprotein E as a lipid transport and signaling protein in the blood, liver, and artery wall
  publication-title: J. Lipid Res.
  doi: 10.1194/jlr.R800058-JLR200
– ident: CR69
– volume: 19
  start-page: 731
  year: 2016
  end-page: 743
  ident: CR9
  article-title: Genetic determinants of the gut microbiome in UK Twins
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2016.04.017
– volume: 7
  start-page: e39191
  year: 2012
  ident: CR14
  article-title: Murine gut microbiota is defined by host genetics and modulates variation of metabolic traits
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0039191
– volume: 20
  start-page: 4115
  year: 2014
  end-page: 4128
  ident: CR32
  article-title: An unconventional KITENIN/ErbB4-mediated downstream signal of EGF upregulates c-Jun and the invasiveness of colorectal cancer cells
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-13-2863
– volume: 6
  start-page: 7113
  year: 2015
  ident: CR59
  article-title: Interplay between enterobactin, myeloperoxidase and lipocalin 2 regulates survival in the inflamed gut
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms8113
– volume: 155
  start-page: 269
  year: 2001
  end-page: 281
  ident: CR48
  article-title: The impact of phospholipid transfer protein (PLTP) on HDL metabolism
  publication-title: Atherosclerosis
  doi: 10.1016/S0021-9150(01)00447-6
– volume: 17
  start-page: 1433
  year: 2012
  end-page: 1440
  ident: CR38
  article-title: How can employ riboflavin for extracellular electron transfer?
  publication-title: Antioxid. Redox Signal.
  doi: 10.1089/ars.2012.4701
– volume: 10
  start-page: e0140301
  year: 2015
  ident: CR11
  article-title: Genome-wide association studies of the human gut microbiota
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0140301
– volume: 39
  start-page: 31
  year: 2007
  end-page: 40
  ident: CR65
  article-title: Convergent adaptation of human lactase persistence in Africa and Europe
  publication-title: Nat. Genet.
  doi: 10.1038/ng1946
– volume: 106
  start-page: 274
  year: 2011
  end-page: 281
  ident: CR68
  article-title: Self-reported energy intake by FFQ compared with actual energy intake to maintain body weight in 516 adults
  publication-title: Br. J. Nutr.
  doi: 10.1017/S0007114511000067
– volume: 81
  start-page: 615
  year: 2007
  end-page: 625
  ident: CR64
  article-title: Evidence of still-ongoing convergence evolution of the lactase persistence T-13910 alleles in humans
  publication-title: Am. J. Hum. Genet.
  doi: 10.1086/520705
– volume: 352
  start-page: 565
  year: 2016
  end-page: 569
  ident: CR3
  article-title: Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity
  publication-title: Science
  doi: 10.1126/science.aad3369
– volume: 17
  start-page: 141
  year: 2013
  end-page: 152
  ident: CR13
  article-title: Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2012.12.007
– ident: CR83
– volume: 65
  start-page: 740
  year: 2015
  end-page: 748
  ident: CR2
  article-title: Proton pump inhibitors affect the gut microbiome
  publication-title: Gut
  doi: 10.1136/gutjnl-2015-310376
– volume: 4
  start-page: 2462
  year: 2013
  ident: CR12
  article-title: Genome-wide mapping of gene–microbiota interactions in susceptibility to autoimmune skin blistering
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms3462
– volume: 530
  start-page: 340
  year: 2016
  end-page: 343
  ident: CR54
  article-title: Visualization of a short-range Wnt gradient in the intestinal stem-cell niche
  publication-title: Nature
  doi: 10.1038/nature16937
– volume: 12
  start-page: 75
  year: 2013
  ident: CR67
  article-title: Relative validity of the food frequency questionnaire used to assess dietary intake in the Leiden Longevity Study
  publication-title: Nutr. J.
  doi: 10.1186/1475-2891-12-75
SSID ssj0014408
Score 2.6616368
Snippet Alexandra Zhernakova, Jingyuan Fu, Cisca Wijmenga and colleagues perform genome-wide association analysis for microbiome characteristics in a cohort with fully...
The gut microbiome is affected by multiple factors, including genetics. In this study, we assessed the influence of host genetics on microbial species,...
SourceID proquest
gale
pubmed
springer
SourceType Aggregation Database
Index Database
Publisher
StartPage 1407
SubjectTerms 45
45/23
45/43
631/208/205/2138
631/208/207
631/208/325
Adolescent
Adult
Aged
Agriculture
Animal Genetics and Genomics
Animals
Archives & records
Bacteria
Biomedicine
Cancer Research
Cohort Studies
Disease
Female
Funding
Gastrointestinal Microbiome
Gene Function
Gene loci
Genetic aspects
Genetics
Genome, Human
Genome-Wide Association Study
Genomes
Genomics
Genotypes
Grants
Growth
Host-bacteria relationships
Human Genetics
Humans
Immunity - genetics
letter
Male
Metabolism
Mice
Microbiota (Symbiotic organisms)
Middle Aged
Nutrition research
Polymorphism, Single Nucleotide
Properties
Studies
Taxonomy
Vocabularies & taxonomies
Young Adult
Title The effect of host genetics on the gut microbiome
URI https://link.springer.com/article/10.1038/ng.3663
https://www.ncbi.nlm.nih.gov/pubmed/27694959
https://www.proquest.com/docview/1833938157
https://www.proquest.com/docview/1835349539
Volume 48
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LT9wwELZ4qBIX1FLabkuRqZA4BdaxM3FOCBAIkEoRFLQ3y3GcqIdNKMke-PfMrLPAIsEll5lEVubzeMbzYmw7AwvKSxcVVhWREnEZ5UPtolK5YWIlWuRAhcK_L-D0Rp2PklF_4db2aZUznThV1EXj6I58D6EnMzxeknT_7n9EU6MoutqP0Fhky9S6jFCdjp4cLopbhlI4ID-JwpSrocxc79XVrgTq_flaEb84iV6FRqcnzslHttqbivwgyPYTW_D1GvsQhkc-fGYCJcxDOgZvSk7VGhzRQEWJLW9qjpYdryYdH_8LvZbGfp3dnBz_PTqN-gEIUaVS2UWQp84mRY5eg4ghFxBTvzqHHgKUuDVFVnh0QLRCF847jYaQylXsh8rFMhEWMvmFLdVN7b8xLnJwQvjMg5TKWq9j4X2W5kLqQurSD9gv-hGGWkLUlHNS2UnbmrM_t-ZAAVmVAMO3mK6v5ph2eqay6e6ts32eP66DWk3NcW7McSKw3Tx5JhTTb6zWPMNgwLaeyPQmJYvVvplMeRJJebPZgH0NwjR3oXeHiVPIkISUrZl0X3ycAvJSm7oyBI7v7y_gB1tB6wlCYeIGW-ruJ_4nWihdvjmFIT71kdhky4fHF5dXj97X4hU
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELaqIgSXijdbCrgIxCl0_cgkOSBUFapd-kCCFvVmHMeJemhSmqyq_qn-RmbWSelWglvPnkRW5rP9OTPfDGNvM7CgvXJRYXURaSHLKB-nLiq1G8dWISMHEgrv7cPkUH89io-W2OWghaG0ymFPnG_URePoH_kGQk9leLzEyafT3xF1jaLo6tBCI8Bix1-c45Wt_Tj9jP59J-X2l4OtSdR3FYgqnagugjxxNi5ypOJCQi5AUhE4h7QbSsS7yAqPrD7VeC_yLkV2oXMt_Vg7qWJhgYov4ZZ_RytcmqRM37pKKaE4aZDeAd3LKCy6EmTt6UZdfVBAtUZvbvzXTr4bodj5Cbf9gK301JRvBiw9ZEu-fsTuhmaVF4-ZQETxkP7Bm5KTOoQj-kgE2fKm5sgkeTXr-MlxqO104p-ww1v5NE_Zct3U_jnjIgcnhM88KKWt9akU3mdJLlRaqLT0I_aGPoShEhQ15bhUdta2Zvrtp9nUQCwWYPwvox_fF4ze90Zl051ZZ3tdAc6DSlstWK4tWOJCcovDg1NMv5Bb8xd2I7Z-NUxPUnJa7ZvZ3CZWlKebjdiz4ExzGmqFGJlAhkM4sj5499rLKQFApaauDIFj9f8TeM3uTQ72ds3udH_nBbuPzA2CKHKNLXdnM_8S2VGXv5pDkrNft70G_gDqZhk4
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Nb9QwELWqIhCXqnwvLeAiEKfQdexMnANCVcuqS6EgoKg313GciEOT0mSF-tf66zqzTkq3Etx69iSyMm_s53jeDGOvMrCgvHRRYVURKRGXUT7WLiqVGydWIiMHEgp_3ofdA_XxMDlcYueDFobSKoc1cb5QF42jf-SbCD2Z4faCB_iyT4v4ujN5f_I7og5SdNM6tNMIENnzZ3_w-Na-m-6gr1_H8eTDj-3dqO8wEFUqlV0EeepsUuRIy0UMuYCYCsI5pOBQIvZFVnhk-FrhGck7jUxD5Sr2Y-VimQgLVIgJl_9bqUw1xZjevkwvoTvTIMMDOqPRFelKkLjrzbp6K4Hqjl7fBK7sgteuZee73WSVrfQ0lW8FXN1jS76-z26HxpVnD5hAdPGQCsKbkpNShCMSSRDZ8qbmyCp5Nev48a9Q5-nYP2QHN_JpHrHluqn9E8ZFDk4In3mQUlnrdSy8z9JcSF1IXfoRe0kfwlA5ipocW9lZ25rpl59mSwExWoDxv4y-f1swetMblU13ap3tNQY4DypztWC5vmCJQeUWhwenmD6oW_MXgiO2cTlMT1KiWu2b2dwmkZSzm43Y4-BMcxLqhpg4hQyHcGRj8O6Vl1MygNSmrgyB4-n_J_CC3UH0m0_T_b01dhdJHAR95Dpb7k5n_hkSpS5_PkckZ0c3HQIXSaMdbg
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+effect+of+host+genetics+on+the+gut+microbiome&rft.jtitle=Nature+genetics&rft.au=Bonder%2C+Marc+Jan&rft.au=Kurilshikov%2C+Alexander&rft.au=Tigchelaar%2C+Ettje+F&rft.au=Mujagic%2C+Zlatan&rft.date=2016-11-01&rft.pub=Nature+Publishing+Group&rft.issn=1061-4036&rft.volume=48&rft.issue=11&rft.spage=1407&rft_id=info:doi/10.1038%2Fng.3663&rft.externalDBID=IOV&rft.externalDocID=A468002660
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1061-4036&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1061-4036&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1061-4036&client=summon