Genetic Variation in KCNQ1 Associates With Fasting Glucose and β-Cell Function: A Study of 3,734 Subjects Comprising Three Ethnicities Living in Singapore

• Published in: Diabetes (New York, N.Y.) Vol. 58; no. 6; pp. 1445 - 1449
• Main Authors: TAN, Jonathan T, NURBAYA, Siti, GARDENER, Daphne, YE, Sandra, TAI, E. Shyong, NG, Daniel P. K
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.06.2009
• Subjects: Asian Continental Ancestry Group - genetics; Biological and medical sciences; Blood Glucose - metabolism; Diabetes Mellitus, Type 2 - epidemiology; Diabetes Mellitus, Type 2 - genetics; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Ethnic Groups - genetics; Etiopathogenesis. Screening. Investigations. Target tissue resistance; European Continental Ancestry Group - genetics; Fasting; Gene Frequency; Genetic aspects; Genetic Predisposition to Disease; Genetic research; Genetic variation; Genetics; Health aspects; Humans; India - ethnology; Insulin-Secreting Cells - physiology; KCNQ1 Potassium Channel - genetics; Linkage Disequilibrium; Medical sciences; Pancreatic beta cells; Quantitative Trait Loci; Risk Factors; Singapore - epidemiology; Type 2 diabetes; Asia; Singapore; India; Endocrinopathy; Human; Fasting; Diabetes mellitus; Langerhans islet; Genetics; β Cell; Glucose; Endocrine pancreas

The potassium voltage-gated channel, KQT-like subfamily, member 1 (KCNQ1) has been found through a genome-wide association study to be a strong candidate for conferring susceptibility to type 2 diabetes in East Asian and European populations. Our objective was to describe the association between pol...