Antecedent Hypoglycemia Impairs Autonomic Cardiovascular Function : Implications for Rigorous Glycemic Control

• Published in: Diabetes (New York, N.Y.) Vol. 58; no. 2; pp. 360 - 366
• Main Authors: ADLER, Gail K, BONYHAY, Istvan, FAILING, Hannah, WARING, Elizabeth, DOTSON, Sarah, FREEMAN, Roy
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.02.2009
• Subjects: Adolescent; Adult; Autonomic Nervous System - metabolism; Autonomic Nervous System - physiopathology; Baroreflex - physiology; Biological and medical sciences; Blood glucose; Blood Glucose - metabolism; Blood sugar; Cardiovascular disease; Cardiovascular diseases; Cardiovascular Diseases - blood; Cardiovascular Diseases - etiology; Cardiovascular Diseases - physiopathology; Complications and side effects; Control; Diabetes; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Epinephrine - blood; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Glucose; Glucose Clamp Technique; Heart Rate - physiology; Humans; Hypoglycemia; Hypoglycemia - blood; Hypoglycemia - complications; Hypoglycemia - physiopathology; Hypotheses; Insulin; Male; Medical sciences; Metabolism; Middle Aged; Mortality; Nervous system; Norepinephrine - blood; Parasympathetic Nervous System - physiopathology; Research design; Risk factors; Sympathetic Nervous System - physiopathology; Womens health; Young Adult; United States; Endocrinopathy; Metabolic diseases; Hypoglycemia; Diabetes mellitus; Antecedent

Glycemic control decreases the incidence and progression of diabetic complications but increases the incidence of hypoglycemia. Hypoglycemia can impair hormonal and autonomic responses to subsequent hypoglycemia. Intensive glycemic control may increase mortality in individuals with type 2 diabetes a...