Insulin secretion and action in subjects with impaired fasting glucose and impaired glucose tolerance : Results from the veterans administration genetic epidemiology study

• Published in: Diabetes (New York, N.Y.) Vol. 55; no. 5; pp. 1430 - 1435
• Main Authors: ABDUL-GHANI, Muhammad A, JENKINSON, Christopher P, RICHARDSON, Dawn K, TRIPATHY, Devjit, DEFRONZO, Ralph A
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.05.2006
• Subjects: Adult; Biological and medical sciences; Blood Glucose - genetics; Blood Glucose - metabolism; Body Mass Index; Catheters; Diabetes; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Epidemiology; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Fasting; Female; Glucose; Glucose Clamp Technique; Glucose intolerance; Glucose Intolerance - blood; Glucose Intolerance - genetics; Glucose Intolerance - physiopathology; Homeostasis; Humans; Insulin resistance; Male; Medical sciences; Metabolism; Mexican Americans - genetics; Middle Aged; Plasma; Risk factors; Texas; Type 2 diabetes; United States; United States Department of Veterans Affairs; Veins & arteries; Veterans; United States; Texas; Endocrinopathy; Human; Pancreatic hormone; Fasting; Secretion; Diabetes mellitus; Genetics; Glucose; Impaired glucose tolerance; Epidemiology; Insulin

This study was conducted to observe changes in insulin secretion and insulin action in subjects with impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT). A total of 319 subjects were studied with an oral glucose tolerance test (OGTT). Fasting plasma glucose and insulin concentrati...