Association of protein tyrosine phosphatase 1B gene polymorphisms with measures of glucose homeostasis in Hispanic Americans: The Insulin Resistance atherosclerosis Study (IRAS) Family Study

• Published in: Diabetes (New York, N.Y.) Vol. 53; no. 11; pp. 3013 - 3019
• Main Authors: PALMER, Nicholette D, BENTO, Jennifer L, MYCHALECKYJ, Josyf C, LANGEFELD, Carl D, CAMPBELL, Joel K, NORRIS, Jill M, HAFFNER, Stephen M, BERGMAN, Richard N, BOWDEN, Donald W
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.11.2004
• Subjects: Atherosclerosis; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; Blood Glucose - metabolism; Cardiology. Vascular system; Chromosome Mapping; Diabetes; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Gene Frequency; Glucose; Glucose - metabolism; Haplotypes; Health aspects; Hispanic Americans; Hispanic people; Homeostasis; Humans; Insulin resistance; Insulin Resistance - genetics; Kinases; Medical sciences; Phenotype; Phosphatase; Phosphorylation; Polymorphism, Single Nucleotide - genetics; Proteins; Signal transduction; United States; United States; Endocrinopathy; American; Enzyme; Diabetes mellitus; Phosphoric monoester hydrolases; Homeostasis; Cardiovascular disease; Esterases; Glucose; Vascular disease; Association; Gene; Atherosclerosis; Hydrolases; Insulin resistance; Polymorphism; Protein-tyrosine-phosphatase

Protein tyrosine phosphatase (PTP)-1B, encoded by the PTPN1 gene, catalyzes the dephosphorylation of proteins at tyrosyl residues. PTP-1B has been implicated in negatively regulating insulin signaling by dephosphorylating the phosphotyrosine residues of the insulin receptor. The genetic contribution...