Omentin-1, a Novel Adipokine, Is Decreased in Overweight Insulin-Resistant Women With Polycystic Ovary Syndrome : Ex Vivo and In Vivo Regulation of Omentin-1 by Insulin and Glucose

• Published in: Diabetes (New York, N.Y.) Vol. 57; no. 4; pp. 801 - 808
• Main Authors: TAN, Bee K, ADYA, Raghu, FARHATULLAH, S, LEWANDOWSKI, Kris C, O'HARE, Paul, LEHNERT, Hendrik, RANDEVA, Harpal S
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.04.2008
• Subjects: Adult; Biological and medical sciences; Blood Glucose - analysis; Body fat; Body Mass Index; Cytokines; Cytokines - blood; Cytokines - genetics; Diabetes. Impaired glucose tolerance; DNA, Complementary - genetics; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Female genital diseases; Gene Expression Regulation; Glucose - physiology; GPI-Linked Proteins; Gynecology. Andrology. Obstetrics; Health aspects; Hormones; Humans; Insulin - blood; Insulin - physiology; Insulin resistance; Insulin Resistance - genetics; Lectins - blood; Lectins - genetics; Lipids - blood; Medical sciences; Metabolic diseases; Non tumoral diseases; Obesity; Obesity - genetics; Overweight - genetics; Patient Selection; Physiological aspects; Polycystic ovary syndrome; Polycystic Ovary Syndrome - blood; Polycystic Ovary Syndrome - genetics; Reference Values; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - genetics; Stein-Leventhal syndrome; United Kingdom; Endocrinopathy; Human; Pancreatic hormone; Diabetes mellitus; Female sterility; Adipokine; Glucose; Polycystic ovary; Insulin; Female genital diseases; Overweight; Ovarian diseases; In vivo; Ex vivo; Cyst; Female; Benign neoplasm
• ISSN: 0012-1797; 1939-327X; 1939-327X
• DOI: 10.2337/db07-0990

Polycystic ovary syndrome (PCOS) is associated with insulin resistance and obesity. Recent studies have shown that plasma omentin-1 levels decrease with obesity. Currently, no data exist on the relative expression and regulation of omentin-1 in adipose tissue of women with PCOS. The objective of thi...