Selective recognition of Triamterene in biological samples by molecularly imprinted monolithic column with a pseudo template employed

• Published in: Journal of separation science Vol. 36; no. 9-10; pp. 1501 - 1508
• Main Authors: Zhao, Xiao-Yun, Zhang, Hong-Wu, Liang, Zhen-Jie, Shu, Ya-Ping, Liang, Yong
• Format: Journal Article
• Language: English
• Published: Weinheim Blackwell Publishing Ltd 01.05.2013; Wiley; Wiley Subscription Services, Inc
• Subjects: Affinity; Analysis; Analytical chemistry; Biological; Biological and medical sciences; Biological samples; Chemistry; Chromatographic methods and physical methods associated with chromatography; Chromatography; Chromatography - instrumentation; Chromatography - methods; Columns (process); Columns (structural); Exact sciences and technology; General pharmacology; Humans; Imprinted polymers; Medical sciences; Molecular chemistry; Molecular Imprinting; Molecularly imprinted polymer; Monolithic column; Other chromatographic methods; Pharmacology. Drug treatments; Polymerization; Polymers; Polymers - chemical synthesis; Polymers - chemistry; Pseudo template; Recognition; Triamterene; Triamterene - blood; Triamterene - urine; Triazines - chemistry; Biological fluid; Chemical analysis; Potassium sparing diuretic; HPLC chromatography; Selectivity; Biological samples; Blood; Surface structure; Affinity adsorbent; Crosslinked copolymer; Methacrylic acid copolymer; Binding capacity; Affinity chromatography; Quantitative analysis; Human; Urine; Scanning electron microscopy; Healthy subject; Characteristic; Monolithic column; Triamterene; Ultraviolet detector; Morphology; Preparation; Molecularly imprinted polymer; Pseudo template; Molecular recognition; Radical copolymerization; Blood serum; Molecular imprinting

Melamine (MAM) was employed as a pseudo template to prepare a molecularly imprinted polymer monolithic column which presents the ability of selective recognition to Triamterene (TAT), whose structure was similar to that of MAM. Methacrylic acid and ethylene glycol dimethacrylate were applied as func...