Enhanced basal activation of mitogen-activated protein kinases in adipocytes from type 2 diabetes: Potential role of p38 in the downregulation of GLUT4 expression

• Published in: Diabetes (New York, N.Y.) Vol. 52; no. 3; pp. 634 - 641
• Main Authors: CARLSON, Christian J, KOTERSKI, Sandra, SCIOTTI, Richard J, POCCARD, German Braillard, RONDINONE, Cristina M
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.03.2003
• Subjects: 3T3 Cells; Adipocytes; Adipocytes - enzymology; Adult; Animals; Biological and medical sciences; Body fat; Development and progression; Diabetes; Diabetes Mellitus, Type 2 - enzymology; Enzyme Activation; Female; Fundamental and applied biological sciences. Psychology; Gene expression; Glucose; Glucose Transporter Type 4; Humans; Insulin - pharmacology; Insulin Receptor Substrate Proteins; Insulin Resistance; JNK Mitogen-Activated Protein Kinases; Kinases; Male; MAP Kinase Kinase 4; Medical research; Mice; Middle Aged; Mitogen-Activated Protein Kinase 1 - metabolism; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases - metabolism; Mitogen-Activated Protein Kinases - metabolism; Monosaccharide Transport Proteins - analysis; Muscle Proteins; p38 Mitogen-Activated Protein Kinases; Phosphoproteins - analysis; Phosphorylation; Physiological aspects; Proteins; Signal transduction; Transduction; Transduction (Genetics); Type 2 diabetes; Argentina

Serine and threonine kinases may contribute to insulin resistance and the development of type 2 diabetes. To test the potential for members of the mitogen-activated protein (MAP) kinase family to contribute to type 2 diabetes, we examined basal and insulin-stimulated Erk 1/2, JNK, and p38 phosphoryl...