GLUT4 is reduced in slow muscle fibers of type 2 diabetic patients: Is insulin resistance in type 2 diabetes a slow, type 1 fiber disease?

• Published in: Diabetes (New York, N.Y.) Vol. 50; no. 6; pp. 1324 - 1329
• Main Authors: GASTER, Michael, STAEHR, Peter, BECK-NIELSEN, Henning, SCHRØDER, Henrick D, HANDBERG, Aase
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.06.2001
• Subjects: Adult; Biological and medical sciences; Blood glucose; Blood sugar; Blotting, Western; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - physiopathology; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Glucose Transporter Type 4; Humans; Insulin; Insulin Resistance; Male; Medical sciences; Middle Aged; Monosaccharide Transport Proteins - metabolism; Muscle Fibers, Fast-Twitch - metabolism; Muscle Fibers, Slow-Twitch - metabolism; Muscle Proteins; Obesity - metabolism; Physiological aspects; Reference Values; Striated muscle; Type 2 diabetes; Denmark; Endocrinopathy; Human; Obesity; Pathophysiology; Muscular fiber; Glucose; Striated muscle; Non insulin dependent diabetes; Insulin; Target tissue resistance; Metabolic disorder; Localization; Morphometry; Carrier protein

To gain further insight into the mechanisms underlying muscle insulin resistance, the influence of obesity and type 2 diabetes on GLUT4 immunoreactivity in slow and fast skeletal muscle fibers was studied. Through a newly developed, very sensitive method using immunohistochemistry combined with morp...