DOCA-salt treatment enhances responses to endothelin-1 in murine corpus cavernosum

• Published in: Canadian journal of physiology and pharmacology Vol. 86; no. 6; pp. 320 - 328
• Main Authors: CARNEIRO, Fernando S, GIACHINI, Fernanda R. C, LIMA, Victor V, CARNEIRO, Zidonia N, NUNES, Kênia P, ERGUL, Adviye, LEITE, Romulo, TOSTES, Rita C, CLINTON WEBB, R
• Format: Conference Proceeding Journal Article
• Language: English
• Published: Ottawa, ON National Research Council of Canada 01.06.2008; NRC Research Press; Canadian Science Publishing NRC Research Press
• Subjects: Animals; Atrasentan; Biological and medical sciences; Desoxycorticosterone - administration & dosage; Endothelin; Endothelin A Receptor Antagonists; Endothelin-1 - administration & dosage; Endothelin-1 - antagonists & inhibitors; Endothelin-1 - genetics; Fundamental and applied biological sciences. Psychology; Health aspects; Hypertension; Hypertension - etiology; Hypertension - physiopathology; Male; Mice; Mice, Inbred C57BL; Muscle, Smooth - drug effects; Muscle, Smooth - physiology; Penile Erection - drug effects; Penile Erection - physiology; Penis; Penis - blood supply; Penis - drug effects; Penis - physiology; Physiological aspects; Properties; Pyrrolidines - administration & dosage; RNA, Messenger - genetics; RNA, Messenger - metabolism; Salt; Sodium Chloride - administration & dosage; Sodium in the body; Steroid hormones; Studies; Vasodilation - drug effects; Vasodilation - physiology; Vertebrates: anatomy and physiology, studies on body, several organs or systems; United States; Hypertension; Enzyme; Transferases; Cardiovascular disease; Corpus cavernosum; Endothelin 1; Atrasentan; Vertebrata; Mammalia; Treatment; Kinase; Peptidergic receptor; Antagonist; Endothelin receptor; Biological receptor

The penis is kept in the flaccid state mainly via a tonic activity of norepinephrine and endothelins (ETs). ET-1 is important in salt-sensitive forms of hypertension. We hypothesized that cavernosal responses to ET-1 are enhanced in deoxycorticosterone acetate (DOCA)-salt mice and that blockade of E...