Memory B Cells in Local and Systemic Sites

• Published in: Advances in experimental medicine and biology Vol. 1254; p. 55
• Main Authors: Moriyama, Saya, Adachi, Yu, Tonouchi, Keisuke, Takahashi, Yoshimasa
• Format: Journal Article
• Language: English
• Published: United States 01.01.2020
• Subjects: Memory B cell; Local tissue-resident memory; Germinal center; Vaccination; Recall response
• ISSN: 0065-2598
• DOI: 10.1007/978-981-15-3532-1_5

Memory B cells are a key cellular component of the protective humoral responses to infectious pathogens. Most of our knowledge of memory B-cell responses comes from studies using mono-epitopic model antigens that elicit systemic humoral responses dominated by canonical B-cell antigen receptors. This...