Preliminary Data on the Senolytic Effects of Agrimonia pilosa Ledeb. Extract Containing Agrimols for Immunosenescence in Middle-Aged Humans: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Comparison Study

• Published in: Nutrients Vol. 17; no. 4; p. 667
• Main Authors: Shimizu, Yoshiki, Shimodan, Shieri, Hayashida, Mariko, Yazaki, Misato, Sakurada, Tsuyoshi, Watanabe, Tomomichi, Ishii, Yuri, Hirose, Yoshie, Saito, Jiro, Teramoto, Sachiyuki
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.02.2025; MDPI
• Subjects: Adult; Aging; Agrimonia - chemistry; Analysis; Autoimmune diseases; beta-Galactosidase - metabolism; CD4-Positive T-Lymphocytes - drug effects; CD8-Positive T-Lymphocytes - drug effects; CD8-Positive T-Lymphocytes - immunology; Chronic fatigue syndrome; Clinical trials; Consent; Double-Blind Method; Ethylenediaminetetraacetic acid; Female; Gender differences; Human subjects; Humans; Immunosenescence - drug effects; Japan; Lymphocytes; Male; Medical history; Medical research; Medicine, Experimental; Middle age; Middle Aged; Older people; Plant Extracts - pharmacology; Senescence; T cells; Japan; United States; immunosenescence; agrimol; senolytic agent; Agrimonia pilosa Ledeb. extract; senescence-associated β-galactosidase

To assess the effects of agrimol-containing Ledeb. extract (APE) for senescent immune cell removal in middle-aged Japanese adults with immunosenescence. A randomized, double-blind, placebo-controlled, parallel-group study was conducted in Japan between June 2023 and April 2024. 110 individuals aged...