Preliminary Data on the Senolytic Effects of Agrimonia pilosa Ledeb. Extract Containing Agrimols for Immunosenescence in Middle-Aged Humans: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Comparison Study - Shimizu, Yoshiki; Shimodan, Shieri; Hayashida, Mariko; Yazaki, Misato; Sakurada, Tsuyoshi; Watanabe, Tomomichi; Ishii, Yuri; Hirose, Yoshie; Saito, Jiro; Teramoto, Sachiyuki (Nutrients, 2025)
Keywords: Adult; Aging; Agrimonia - chemistry; Analysis; Autoimmune diseases; beta-Galactosidase - metabolism; CD4-Positive T-Lymphocytes - drug effects; CD8-Positive T-Lymphocytes - drug effects; CD8-Positive T-Lymphocytes - immunology; Chronic fatigue syndrome; Clinical trials; Consent; Double-Blind Method; Ethylenediaminetetraacetic acid; Female; Gender differences; Human subjects; Humans; Immunosenescence - drug effects; Japan; Lymphocytes; Male; Medical history; Medical research; Medicine, Experimental; Middle age; Middle Aged; Older people; Plant Extracts - pharmacology; Senescence; T cells; Japan; United States; immunosenescence; agrimol; senolytic agent; Agrimonia pilosa Ledeb. extract; senescence-associated β-galactosidase