Neuropsychiatric adverse effects of interferon-α: Recognition and management

• Published in: CNS drugs Vol. 19; no. 2; pp. 105 - 123
• Main Authors: RAISON, Charles L, DEMETRASHVILI, Marina, CAPURON, Lucile, MILLER, Andrew H
• Format: Journal Article
• Language: English
• Published: Hong Kong Adis International 01.01.2005; Auckland Wolters Kluwer Health, Inc
• Subjects: Antiviral Agents - adverse effects; Behavioral Symptoms - chemically induced; Behavioral Symptoms - epidemiology; Behavioral Symptoms - prevention & control; Biological and medical sciences; Drug toxicity and drugs side effects treatment; Hepatitis C, Chronic - drug therapy; Humans; Interferon-alpha - adverse effects; Medical sciences; Mood Disorders - chemically induced; Mood Disorders - physiopathology; Neoplasms - drug therapy; Pharmacology. Drug treatments; Prevalence; Psychiatric Status Rating Scales; Recognition (Psychology); Risk Factors; Toxicity: nervous system and muscle; Human; Confusion psychosis; Alpha interferon; Toxicity; Mental disorder; Mania; Depression; Review

Recombinant preparations of the cytokine interferon (IFN)-alpha are increasingly used to treat a number of medical conditions, including chronic viral hepatitis and several malignancies. Although frequently effective, IFN alpha induces a variety of neuropsychiatric adverse effects, including an acut...