A systematic review of the exercise effects on burn wound healing
The emerging evidence has indicated the role of microRNAs (miRNA) in various physiological or pathological processes. Also, documents have suggested that exercise, by affecting miRNA regulation, may enhance burn wound healing. The current study aims to systematically review the role of exercise in r...
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Published in | International wound journal Vol. 21; no. 3; pp. e14482 - n/a |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Publishing Ltd
01.03.2024
John Wiley & Sons, Inc |
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Abstract | The emerging evidence has indicated the role of microRNAs (miRNA) in various physiological or pathological processes. Also, documents have suggested that exercise, by affecting miRNA regulation, may enhance burn wound healing. The current study aims to systematically review the role of exercise in regulating miRNAs related to burn wound healing to provide potential therapeutic targets. A comprehensive, systematic search was performed in different international electronic databases, such as Embase, PubMed and Google Scholar search engine, Science Direct, ProQuest and Ovid using keywords extracted from Medical Subject Headings from 2010 to September 2023. The keywords, including ‘exercise’ AND ‘burn wound’ AND ‘microRNA’ and finally, six cases were achieved. Evidence has indicated that exercise may promote the healing of burn wounds by regulating certain miRNAs. Studies have found that exercise regulates the expression of miRNAs such as mir‐155, miR‐21, let‐7a, miR‐146a, miR‐122 and mir‐210 in burn wound tissue, which regulate inflammation and angiogenesis. These findings suggest that miRNAs may play a role in the positive effect of exercise on burn wound healing. However, further research is needed to understand the mechanisms involved fully. |
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AbstractList | The emerging evidence has indicated the role of microRNAs (miRNA) in various physiological or pathological processes. Also, documents have suggested that exercise, by affecting miRNA regulation, may enhance burn wound healing. The current study aims to systematically review the role of exercise in regulating miRNAs related to burn wound healing to provide potential therapeutic targets. A comprehensive, systematic search was performed in different international electronic databases, such as Embase, PubMed and Google Scholar search engine, Science Direct, ProQuest and Ovid using keywords extracted from Medical Subject Headings from 2010 to September 2023. The keywords, including 'exercise' AND 'burn wound' AND 'microRNA' and finally, six cases were achieved. Evidence has indicated that exercise may promote the healing of burn wounds by regulating certain miRNAs. Studies have found that exercise regulates the expression of miRNAs such as mir-155, miR-21, let-7a, miR-146a, miR-122 and mir-210 in burn wound tissue, which regulate inflammation and angiogenesis. These findings suggest that miRNAs may play a role in the positive effect of exercise on burn wound healing. However, further research is needed to understand the mechanisms involved fully. The emerging evidence has indicated the role of microRNAs (miRNA) in various physiological or pathological processes. Also, documents have suggested that exercise, by affecting miRNA regulation, may enhance burn wound healing. The current study aims to systematically review the role of exercise in regulating miRNAs related to burn wound healing to provide potential therapeutic targets. A comprehensive, systematic search was performed in different international electronic databases, such as Embase, PubMed and Google Scholar search engine, Science Direct, ProQuest and Ovid using keywords extracted from Medical Subject Headings from 2010 to September 2023. The keywords, including 'exercise' AND 'burn wound' AND 'microRNA' and finally, six cases were achieved. Evidence has indicated that exercise may promote the healing of burn wounds by regulating certain miRNAs. Studies have found that exercise regulates the expression of miRNAs such as mir-155, miR-21, let-7a, miR-146a, miR-122 and mir-210 in burn wound tissue, which regulate inflammation and angiogenesis. These findings suggest that miRNAs may play a role in the positive effect of exercise on burn wound healing. However, further research is needed to understand the mechanisms involved fully.The emerging evidence has indicated the role of microRNAs (miRNA) in various physiological or pathological processes. Also, documents have suggested that exercise, by affecting miRNA regulation, may enhance burn wound healing. The current study aims to systematically review the role of exercise in regulating miRNAs related to burn wound healing to provide potential therapeutic targets. A comprehensive, systematic search was performed in different international electronic databases, such as Embase, PubMed and Google Scholar search engine, Science Direct, ProQuest and Ovid using keywords extracted from Medical Subject Headings from 2010 to September 2023. The keywords, including 'exercise' AND 'burn wound' AND 'microRNA' and finally, six cases were achieved. Evidence has indicated that exercise may promote the healing of burn wounds by regulating certain miRNAs. Studies have found that exercise regulates the expression of miRNAs such as mir-155, miR-21, let-7a, miR-146a, miR-122 and mir-210 in burn wound tissue, which regulate inflammation and angiogenesis. These findings suggest that miRNAs may play a role in the positive effect of exercise on burn wound healing. However, further research is needed to understand the mechanisms involved fully. |
Author | Niumanlan Farzan, Ramyar Hao, Qin Alizadeh Otaghvar, Hamidreza Jingming, Yan |
AuthorAffiliation | 1 Anhui Xinhua University Hefei China 4 Plastic Surgery, Trauma and Injury Research Center Iran University of Medical Sciences Tehran Iran 3 Department of Plastic and Reconstructive Surgery, School of Medicine Guilan University of Medical Sciences Rasht Iran 2 Taiji Martial Arts Institute of Jiaozuo University Jiaozuo China |
AuthorAffiliation_xml | – name: 4 Plastic Surgery, Trauma and Injury Research Center Iran University of Medical Sciences Tehran Iran – name: 1 Anhui Xinhua University Hefei China – name: 2 Taiji Martial Arts Institute of Jiaozuo University Jiaozuo China – name: 3 Department of Plastic and Reconstructive Surgery, School of Medicine Guilan University of Medical Sciences Rasht Iran |
Author_xml | – sequence: 1 surname: Niumanlan fullname: Niumanlan organization: Anhui Xinhua University – sequence: 2 givenname: Yan surname: Jingming fullname: Jingming, Yan organization: Anhui Xinhua University – sequence: 3 givenname: Qin surname: Hao fullname: Hao, Qin organization: Taiji Martial Arts Institute of Jiaozuo University – sequence: 4 givenname: Ramyar orcidid: 0000-0002-7347-6574 surname: Farzan fullname: Farzan, Ramyar email: ramyarfarzan@yahoo.com organization: Guilan University of Medical Sciences – sequence: 5 givenname: Hamidreza orcidid: 0000-0001-8535-3881 surname: Alizadeh Otaghvar fullname: Alizadeh Otaghvar, Hamidreza email: drhralizade@yahoo.com organization: Iran University of Medical Sciences |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37957133$$D View this record in MEDLINE/PubMed |
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Copyright | 2023 The Authors. published by Medicalhelplines.com Inc and John Wiley & Sons Ltd. 2023 The Authors. International Wound Journal published by Medicalhelplines.com Inc and John Wiley & Sons Ltd. 2024. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
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References | 2021; 25 2023; 31 2017; 6 2004; 63 2021; 22 2010; 107 2000; 5 2023; 37 2023; 7 2019; 12 2018; 123 1997; 276 2022; 24 2022; 68 2019; 19 2020; 129 2013; 366 2012; 17 2022; 21 2012; 15 2020; 10 2013; 7 2018; 47 2023; 20 2013; 18 2018; 9 2017; 30 2014; 3 2013; 54 2013; 13 2022; 84 2019; 23 2022; 79 2014; 19 2016; 197 2011; 286 2016; 151 2021; 9 2019; 8 2021; 6 2023; 14 2023; 11 2021; 2 2023; 59 2022; 48 2020; 34 2014; 2014 2015; 888 2022; 44 2012; 33 2022; 49 2018; 27 2009; 27 2016; 4 2012; 2 2023; 44 2019; 40 2022; 2022 2021; 11 2023 2020; 30 2017; 58 2021 2023; 49 1991; 63 2021; 18 2022; 8 2019; 45 2005; 8 2022; 13 2022; 14 2011; 43 2014; 35 2022; 10 2022; 11 2016; 291 2011; 585 40031931 - Int Wound J. 2025 Mar;22(3):e70275. doi: 10.1111/iwj.70275. |
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SubjectTerms | Adult Angiogenesis Burns Burns - physiopathology Burns - therapy Cytokines DNA methylation Epigenetics Exercise Exercise - physiology Exercise Therapy - methods Female Gene expression Humans Infections Inflammation Injuries Leukocytes Male MicroRNAs MicroRNAs - metabolism Middle Aged Neutrophils Pathogens Physical fitness Review Search strategies Systematic review Wound healing Wound Healing - physiology wounds wounds healing |
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Title | A systematic review of the exercise effects on burn wound healing |
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