Endothelin‐1‐induced ETA receptor‐mediated nociception, hyperalgesia and oedema in the mouse hind‐paw: modulation by simultaneous ETB receptor activation

• Published in: British journal of pharmacology Vol. 129; no. 5; pp. 961 - 968
• Main Authors: Piovezan, Anna P, D'Orléans‐Juste, Pedro, Souza, Glória E P, Rae, Giles A
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.03.2000; Nature Publishing
• Subjects: Biological and medical sciences; capsaicin; Endothelin; endothelin receptor antagonist; hyperalgesia; inflammation; Medical sciences; Neuropharmacology; Neurotransmitters. Neurotransmission. Receptors; nociception; oedema; pain; Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems; Pharmacology. Drug treatments; Edema; Agonist; Capsaicin; Toxicity; Rodentia; Activation; Endothelin 1; Inflammation; Hyperalgesia; Vertebrata; Mammalia; Pain; Mouse; Animal; Peptidergic receptor; Antagonist; Mechanism of action

Endothelin‐1 causes ETA receptor‐mediated enhancement of capsaicin‐induced nociception in mice. We have assessed if this hyperalgesic effect of endothelin‐1 is also accompanied by other pro‐inflammatory effects, namely nociception and oedema, and characterized the endothelin ET receptors involved. I...