Extracellular proteases are key mediators of Staphylococcus aureus virulence via the global modulation of virulence‐determinant stability

• Published in: MicrobiologyOpen (Weinheim) Vol. 2; no. 1; pp. 18 - 34
• Main Authors: Kolar, Stacey L., Antonio Ibarra, J., Rivera, Frances E., Mootz, Joe M., Davenport, Jessica E., Stevens, Stanley M., Horswill, Alexander R., Shaw, Lindsey N.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.02.2013
• Subjects: Animals; Culture Media - chemistry; Disease Models, Animal; Female; Gene Knockout Techniques; Humans; Leukocytes - immunology; Leukocytes - microbiology; Methicillin-Resistant Staphylococcus aureus - enzymology; Methicillin-Resistant Staphylococcus aureus - growth & development; Methicillin-Resistant Staphylococcus aureus - metabolism; Methicillin-Resistant Staphylococcus aureus - pathogenicity; Mice; Original Research; Pathogenesis; Peptide Hydrolases - genetics; Peptide Hydrolases - metabolism; Phagocytosis; protease; Protein Stability; Proteolysis; Staphylococcal Infections - microbiology; Staphylococcal Infections - pathology; Survival Analysis; Virulence; virulence determinant; Virulence Factors - genetics; Virulence Factors - metabolism

Staphylococcus aureus is a highly virulent and successful pathogen that causes a diverse array of diseases. Recently, an increase of severe infections in healthy subjects has been observed, caused by community‐associated methicillin‐resistant S. aureus (CA‐MRSA). The reason for enhanced CA‐MRSA viru...