Pharmacokinetics and Pharmacodynamics in Breast Cancer Animal Models

• Published in: Methods in molecular biology (Clifton, N.J.) Vol. 1406; p. 271
• Main Authors: Wang, Wei, Nag, Subhasree, Zhang, Ruiwen
• Format: Journal Article
• Language: English
• Published: United States 2016
• Subjects: Animals; Antineoplastic Agents - metabolism; Antineoplastic Agents - pharmacokinetics; Antineoplastic Agents - pharmacology; Biological Transport; Breast Neoplasms - pathology; Cell Line, Tumor; Cytochrome P-450 Enzyme Inhibitors - pharmacology; Cytochrome P-450 Enzyme System - biosynthesis; Cytochrome P-450 Enzyme System - metabolism; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Discovery - methods; Enzyme Induction - drug effects; Feces - chemistry; Female; Humans; Mice; Xenograft Model Antitumor Assays - methods; PK/PD modeling; Animal models; Pharmacodynamics; Breast cancer; Pharmacokinetics

The study of pharmacokinetics (PK) and pharmacodynamics (PD) in cancer drug discovery and development is often paired and described in reciprocal terms, where PK is the analysis of the change in drug concentration with time and PD is the analysis of the biological effects of the drug at various conc...