TCR/ITK Signaling in Type 1 Regulatory T cells

• Published in: Advances in experimental medicine and biology Vol. 1278; p. 115
• Main Authors: McGee, Michael C, August, Avery, Huang, Weishan
• Format: Journal Article
• Language: English
• Published: United States 01.01.2021
• Subjects: Animals; Mice; Protein-Tyrosine Kinases - metabolism; Receptors, Antigen, T-Cell - genetics; Signal Transduction; T-Lymphocytes, Regulatory - metabolism; ITK; TCR; IRF4; Ras; Tr1 cells

Type 1 regulatory T (Tr1) cells can modulate inflammation through multiple direct and indirect molecular and cellular mechanisms and have demonstrated potential for anti-inflammatory therapies. Tr1 cells do not express the master transcription factor of conventional regulatory T cells, Foxp3, but ex...