Targeting TRPC-5 Channel Inhibition to Improve Penile Vascular Function in Erectile Dysfunction

• Published in: International journal of molecular sciences Vol. 26; no. 4; p. 1431
• Main Authors: El Assar, Mariam, García-Gómez, Borja, La Fuente, José M, Alonso-Isa, Manuel, Martínez-Salamanca, Juan I, Fernández, Argentina, Sosa, Patricia, Romero-Otero, Javier, Rodríguez-Mañas, Leocadio, Angulo, Javier
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 08.02.2025; MDPI
• Subjects: Adult; Aged; Aging; Analysis; Animals; Blood & organ donations; Cardiovascular disease; Diabetes; Endothelium; Endothelium, Vascular - drug effects; Endothelium, Vascular - metabolism; Erectile dysfunction; Erectile Dysfunction - drug therapy; Erectile Dysfunction - metabolism; Erectile Dysfunction - physiopathology; Ethylenediaminetetraacetic acid; Health aspects; Humans; Impotence; Male; Middle Aged; Pathophysiology; Penis; Penis - blood supply; Penis - drug effects; Penis - metabolism; Penis - physiopathology; Phosphodiesterase 5 Inhibitors - pharmacology; Rats; Smooth muscle; Transplantation of organs, tissues, etc; TRPC Cation Channels - antagonists & inhibitors; TRPC Cation Channels - metabolism; Vasodilation - drug effects; Veins & arteries; United States; Spain; neurogenic relaxation; TRPC5; canonical transient receptor potential (TRPC) channels; human corpus cavernosum; aging; human penile arteries; endothelial dysfunction; erectile dysfunction

Canonical transient receptor potential (TRPC) channels contribute to calcium homeostasis, which is involved in penile vascular contractility and erectile dysfunction (ED) pathophysiology. We evaluated the impact of TRPC5 inhibition on endothelial function in penile vascular tissue from aging rats an...