Targeting TRPC-5 Channel Inhibition to Improve Penile Vascular Function in Erectile Dysfunction - El Assar, Mariam; García-Gómez, Borja; La Fuente, José M; Alonso-Isa, Manuel; Martínez-Salamanca, Juan I; Fernández, Argentina; Sosa, Patricia; Romero-Otero, Javier; Rodríguez-Mañas, Leocadio; Angulo, Javier (International journal of molecular sciences, 2025)
Keywords: Adult; Aged; Aging; Analysis; Animals; Blood & organ donations; Cardiovascular disease; Diabetes; Endothelium; Endothelium, Vascular - drug effects; Endothelium, Vascular - metabolism; Erectile dysfunction; Erectile Dysfunction - drug therapy; Erectile Dysfunction - metabolism; Erectile Dysfunction - physiopathology; Ethylenediaminetetraacetic acid; Health aspects; Humans; Impotence; Male; Middle Aged; Pathophysiology; Penis; Penis - blood supply; Penis - drug effects; Penis - metabolism; Penis - physiopathology; Phosphodiesterase 5 Inhibitors - pharmacology; Rats; Smooth muscle; Transplantation of organs, tissues, etc; TRPC Cation Channels - antagonists & inhibitors; TRPC Cation Channels - metabolism; Vasodilation - drug effects; Veins & arteries; United States; Spain; neurogenic relaxation; TRPC5; canonical transient receptor potential (TRPC) channels; human corpus cavernosum; aging; human penile arteries; endothelial dysfunction; erectile dysfunction