A functional polymorphism of the vasoactive intestinal peptide receptor 1 gene correlates with the presence of HLA-B2705 in Sardinia

• Published in: Genes and immunity Vol. 9; no. 8; pp. 659 - 667
• Main Authors: Paladini, F, Cocco, E, Cauli, A, Cascino, I, Vacca, A, Belfiore, F, Fiorillo, M T, Mathieu, A, Sorrentino, R
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.12.2008
• Subjects: Alleles; Down-Regulation; Evaluation; Female; Founder Effect; Gene Frequency; Genetic polymorphisms; Genetic Predisposition to Disease; Genetic research; Genotype; Haplotypes; HLA-B27 Antigen - genetics; Humans; Italy; Male; Polymorphism, Single Nucleotide; Properties; Spondylitis, Ankylosing - genetics; Vasoactive Intestinal Peptide - genetics; Vasoactive intestinal peptides; Italy

The association of HLA-B27 with ankylosing spondylitis (AS) is the strongest among all inflammatory diseases. However, the exact role of these molecules in disease pathogenesis is still unknown. The existence of HLA-B27 variants rarely found in patients introduces a further level of complexity. It i...