Cyclometalated AuIII Complexes for Cysteine Arylation in Zinc Finger Protein Domains: towards Controlled Reductive Elimination

• Published in: Chemistry : a European journal Vol. 25; no. 32; pp. 7628 - 7634
• Main Authors: Wenzel, Margot N., Bonsignore, Riccardo, Thomas, Sophie R., Bourissou, Didier, Barone, Giampaolo, Casini, Angela
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 07.06.2019; John Wiley and Sons Inc
• Subjects: Aqueous solutions; catalysis; Chemistry; Communication; Communications; Cysteine; cysteine arylation; Cytotoxicity; Gold; gold complexes; Ionization; Ions; Mass spectrometry; Mass spectroscopy; Proteins; Quantum mechanics; reductive elimination; Zinc; Zinc finger proteins

With the aim of exploiting the use of organometallic species for the efficient modification of proteins through C‐atom transfer, the gold‐mediated cysteine arylation through a reductive elimination process occurring from the reaction of cyclometalated AuIII C^N complexes with a zinc finger peptide (...