Function of Krüppel‑like factor 2 in the shear stress‑induced cell differentiation of endothelial progenitor cells to endothelial cells

• Published in: Molecular medicine reports Vol. 19; no. 3; pp. 1739 - 1746
• Main Authors: Chu, Hai-Rong, Sun, Yu-Cong, Gao, Yu, Guan, Xiu-Mei, Yan, Hong, Cui, Xiao-Dong, Zhang, Xiao-Yun, Li, Xin, Li, Hong, Cheng, Min
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications 01.03.2019; Spandidos Publications UK Ltd
• Subjects: Actin; Anopheles; Antibodies; Atherosclerosis; Binding sites; Bone marrow; Cardiovascular disease; Cell differentiation; Cells (Biology); Cytochalasin D; Cytoskeleton; Endothelial cells; Endothelium; Flow cytometry; Gene expression; Genetic aspects; Health aspects; Integrins; Krueppel-like factor; Laboratory animals; Luciferase; Messenger RNA; Muscle proteins; Polymerase chain reaction; Progenitor cells; Reverse transcription; RNA; Shear stress; siRNA; Stem cells; Studies; Transcription factors; Von Willebrand factor; China; Germany

The present study aimed to evaluate the effects of Krüppel‑like factor 2 (KLF2) on the differentiation of endothelial progenitor cells (EPCs) to endothelial cells (ECs) induced by shear stress, and to investigate the corresponding mechanisms. Cultured rat late EPCs were exposed to shear stress (12 d...