Levels of Cytokines and MicroRNAs in Individuals With Asymptomatic Hyperuricemia and Ultrasonographic Findings of Gout: A Bench‐to‐Bedside Approach

• Published in: Arthritis care & research (2010) Vol. 70; no. 12; pp. 1814 - 1821
• Main Authors: Estevez‐Garcia, Irving O., Gallegos‐Nava, Selma, Vera‐Pérez, Erika, Silveira, Luis H., Ventura‐Ríos, Lucio, Vancini, Gonzalo, Hernández‐Díaz, Cristina, Sánchez‐Muñoz, Fausto, Ballinas‐Verdugo, Martha A., Gutierrez, Marwin, Pineda, Carlos, Rodriguez‐Henriquez, Pedro, Castillo‐Martínez, Diana, Amezcua‐Guerra, Luis M.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.12.2018
• Subjects: Adult; Aged; Asymptomatic Diseases; Biomarkers - blood; Case-Control Studies; Cell signaling; Chronic Disease; Circulating MicroRNA - blood; Cross-Sectional Studies; Crystallization; Cytokines; Cytokines - blood; Deposits; Female; Gout; Gout - blood; Gout - diagnostic imaging; Gout - etiology; Humans; Hyperuricemia; Hyperuricemia - blood; Hyperuricemia - complications; Hyperuricemia - diagnosis; Hyperuricemia - diagnostic imaging; Inflammation; Interferon; Joints - chemistry; Joints - diagnostic imaging; Male; Mexico; Middle Aged; miRNA; Monocyte chemoattractant protein; Monocyte chemoattractant protein 1; Monocytes; Predictive Value of Tests; Synovitis; Synovitis - blood; Synovitis - diagnostic imaging; Synovitis - etiology; Ultrasonography, Doppler; Ultrasound; Uric acid; Uric Acid - analysis; Mexico

Objective To assess potential associations among serum cytokines and microRNA (miR) levels with ultrasound (US) findings suggestive of urate deposits in chronic asymptomatic hyperuricemia and gout. Methods All participants underwent musculoskeletal US and measurements of serum interleukin‐1β (IL‐1β)...